Hydrogel crosslinking modulates macrophages, fibroblasts, and their communication, during wound healing
Biomaterial wound dressings, such as hydrogels, interact with host cells to regulate tissue
repair. This study investigates how crosslinking of gelatin-based hydrogels influences …
repair. This study investigates how crosslinking of gelatin-based hydrogels influences …
Exploiting temporal aspects of cancer immunotherapy
RM Zemek, V Anagnostou, I Pires da Silva… - Nature Reviews …, 2024 - nature.com
Many mechanisms underlying an effective immunotherapy-induced antitumour response are
transient and critically time dependent. This is equally true for several immunological events …
transient and critically time dependent. This is equally true for several immunological events …
Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain
Brain metastasis, a serious complication of cancer, hinges on the initial survival,
microenvironment adaptation, and outgrowth of disseminated cancer cells. To understand …
microenvironment adaptation, and outgrowth of disseminated cancer cells. To understand …
Targeting CD206+ macrophages disrupts the establishment of a key antitumor immune axis
CD206 is a common marker of a putative immunosuppressive “M2” state in tumor-
associated macrophages (TAMs). We made a novel conditional CD206 (Mrc1) knock-in …
associated macrophages (TAMs). We made a novel conditional CD206 (Mrc1) knock-in …
Skeletal muscle niche, at the crossroad of cell/cell communications
M Theret, B Chazaud - Current Topics in Developmental Biology, 2024 - Elsevier
Skeletal muscle is composed of a variety of tissue and non-tissue resident cells that
participate in homeostasis. In particular, the muscle stem cell niche is a dynamic system …
participate in homeostasis. In particular, the muscle stem cell niche is a dynamic system …
[HTML][HTML] Integrated single-cell analysis reveals spatially and temporally dynamic heterogeneity in fibroblast states during wound healing
Wound healing is a dynamic process over temporal and spatial scales. Key to repair
outcomes are fibroblasts; yet, how they modulate healing across time and in different wound …
outcomes are fibroblasts; yet, how they modulate healing across time and in different wound …
Serine protease 35 regulates the fibroblast matrisome in response to hyperosmotic stress
CS Sänger, M Cernakova, MS Wietecha… - Science …, 2023 - science.org
Hyperosmotic stress occurs in several diseases, but its long-term effects are largely
unknown. We used sorbitol-treated human fibroblasts in 3D culture to study the …
unknown. We used sorbitol-treated human fibroblasts in 3D culture to study the …
Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma
Y Hachemi, S Perrin, M Ethel, A Julien, J Vettese… - Bone Research, 2024 - nature.com
Musculoskeletal traumatic injuries (MTI) involve soft tissue lesions adjacent to a bone
fracture leading to fibrous nonunion. The impact of MTI on the inflammatory response to …
fracture leading to fibrous nonunion. The impact of MTI on the inflammatory response to …
[HTML][HTML] A nanoenzyme-modified hydrogel targets macrophage reprogramming-angiogenesis crosstalk to boost diabetic wound repair
S He, Z Li, L Wang, N Yao, H Wen, H Yuan, J Zhang… - Bioactive Materials, 2024 - Elsevier
Diabetic wounds has a gradually increasing incidence and morbidity. Excessive
inflammation due to immune imbalance leads to delayed wound healing. Here, we reveal …
inflammation due to immune imbalance leads to delayed wound healing. Here, we reveal …
Spatiotemporal single-cell roadmap of human skin wound healing
Wound healing is vital for human health, yet the details of cellular dynamics and
coordination in human wound repair remain largely unexplored. To address this, we …
coordination in human wound repair remain largely unexplored. To address this, we …