The previous decade has seen a rapid increase in microglial studies on pain, with a unique
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …

Neuropathic pain refers to a variety of chronic pain conditions with differing underlying
pathophysiologic mechanisms and origins. Recent studies indicate a communication …

Pain normally subserves a vital role in the survival of the organism, prompting the avoidance
of situations associated with tissue damage. However, the sensation of pain can become …

Chemokines and chemokine receptors are widely expressed by cells of the immune and
nervous systems. This review focuses on our current knowledge concerning the role of …

While neuroimmune interactions are increasingly recognized as important in nociceptive
processing, the nature and functional significance of these interactions is not well defined …

Neurons in sensory ganglia are surrounded by satellite glial cells (SGCs) that perform
similar functions to the glia found in the CNS. When primary sensory neurons are injured …

Chronic pain, a pathological state, affects millions of people worldwide. Despite decades of
study on the neuronal processing of pain, mechanisms underlying the creation and …

The bone is a complex organ that is dependent on a tight regulation between bone
formation by osteoblasts (OBs) and bone resorption by osteoclasts (OCs). These processes …

Personalised and targeted interventions have revolutionised cancer treatment and
dramatically improved survival rates in recent decades. Nonetheless, effective pain …

Abstract Willey, JS, Lloyd, SAJ, Robbins, ME, Bourland, JD, Smith-Sielicki, H., Bowman, LC,
Norrdin, RW and Bateman, TA Early Increase in Osteoclast Number in Mice after Whole …