Fed-batch cultivation is a well-known type of submerged fermentation that is frequently used
in manufacture of recombinant proteins and various kinds of enzymes, owing to its ability to …

This paper aims to determine a time-varying dilution rate of the feed medium which
maximizes mean productivity while minimizing both system sensitivity and control cost in …

Optimal control technique is crucial to improve the yield of microbial fermentation production.
In this paper, we propose a nonlinear control system with state-dependent impulses, where …

The optimal control strategy constructed in the form of a state feedback is effective for small
state perturbations caused by changes in modeling uncertainty. In this paper, we investigate …

In this paper, we considered a time-optimal control problem for a new type of linear
parameter varying (LPV) system which is obtained through data identification in the process …

The modeling of microbial fed-batch fermentation with switching operators to product 1, 3-
propanediol (1, 3-PD) still maintains a challenge because it is strongly of nonlinearity and …

Abstract Bioconversion of glycerol to 1, 3-propanediol is a promising way to mitigate the
shortage of energy. To maximize the production of 1, 3-propanediol, it needs to control …

This paper focuses on binary optimal control of fed-batch fermentation of glycerol by
Klebsiella pneumoniae with pH feedback considering limited number of switches. To …

In this paper, we consider a nonlinear time-delay dynamic (NTDD) system with uncertain
time-delay in batch culture of glycerol bioconversion to 1; 3-propanediol (1; 3-PD) induced …

For the bio‐dissimilation of glycerol to 1, 3‐propanediol by Klebsiella pneumoniae, the
nonlinear dynamical system of the complex metabolism in microbial batch fermentation is …