Connective tissue growth factor: Potential role in glomerulosclerosis and tubulointerstitial
fibrosis. Transforming growth factor beta (TGF-β) is a pivotal driver of glomerulosclerosis and …

Role of immunocompetent cells in nonimmune renal diseases. Renal infiltration with
macrophages and monocytes is a well-recognized feature of not only immune, but also …

Mycophenolate mofetil prevents the progressive renal failure induced by 5/6 renal ablation
in rats. Background Extensive renal ablation is associated with progressive sclerosis of the …

MIP-1α and MCP-1 contribute to crescents and interstitial lesions in human crescentic
glomerulonephritis. Background The precise molecular mechanisms of macrophage (Mϕ) …

The role of EGF in the evolution of renal lesions after injury is still controversial. To
determine whether the EGF expression is beneficial or detrimental, we generated transgenic …

That reactive oxygen species are involved in progressive renal injury is supported by
several lines of evidence: increased generation of oxidants occurs in chronic renal injury; …

Background/Aims—Mast cells, when activated, secrete a large number of fibrogenic factors
and have been implicated in the development of fibrotic conditions of the liver, lung, and …

Interactions between inflammatory infiltrates and resident tubular epithelial cells may play
important roles in the development of tubulointerstitial fibrosis, by promoting epithelial cell …

Role of MAP kinase pathways in mediating IL-6 production in human primary mesangial and
proximal tubular cells. Background Both interleukin-6 (IL-6) and tumor necrosis factor-α (TNF …

TNF-α and IL-1β–mediated regulation of MMP-9 and TIMP-1 in renal proximal tubular cells.
Background Tubulointerstitial fibrosis is a morphologic hallmark of chronic kidney disease …