Highlights•Pharmacological treatment of chronic pain and migraine remains unsatisfactory.•
Chronic pain and migraine share some common pathophysiological mechanisms.•Drug …

Background Several neurotransmitters are expressed in the neurons of the trigeminal
ganglion. One such signalling molecule is the pituitary adenylate cyclase-activating peptide …

The trigeminal ganglia (TG) subserving the head and the dorsal root ganglia (DRG)
subserving the rest of the body are homologous handling sensory neurons. Differences …

The pharmacological agent nitroglycerin (NTG) elicits hyperalgesia and allodynia in mice.
This model has been used to study the neurological disorder of trigeminovascular pain or …

Background Based on the current understanding of the role of neuropeptide signalling in
migraine, we explored the therapeutic potential of a specific cannabinoid agonist. The aim of …

The pain sensation system is highly conserved among species, thus animal models have
been used to investigate relevant tissues. The focus for head-specific pain has been on the …

Hayvan modelleri, insana zarar verme riski olmadan insanda görülen hastalıkların
incelenmesinde ve yeni terapötik yaklaşımların geliştirilmesinde kullanılan önemli araştırma …

Background Migraineurs are highly sensitive to the nitric oxide donor glyceryl trinitrate which
triggers attacks in many sufferers. In animal studies, glyceryl trinitrate increases neuronal …

Migraine is a serious episodic headaches affecting more than 15% of the human population
with a detrimental influence on the patients' life and socioeconomic functioning. Although …