Despite the availability of a safe and effective vaccine, yellow fever remains a major vaccine-
preventable disease in endemic regions. Additionally, travelers risk acquiring yellow fever …

Background The arboviruses continue to be a threat to public health and socioeconomic
development in sub-Saharan Africa (SSA). Seroprevalence surveys can be used as a …

Single-dose, immunogenic DNA (iDNA) vaccines coding for whole live-attenuated viruses
are reviewed. This platform, sometimes called immunization DNA, has been used for …

Flavivirus particle maturation, a process essential for virus infectivity, has been mostly
studied using dengue virus. In infected cells, immature icosahedral virions bud into the …

Yellow fever (YF), a vector-borne viral hemorrhagic fever, is endemic in tropical regions of
Africa and South America, with large vaccination programmes being used for control …

Decoration of nucleoside analogues with lipophilic groups often leads to compounds with
improved antiviral activity. For example, N 6-benzyladenosine derivatives containing …

Neuroinfections rank among the top ten leading causes of child mortality globally, even in
high-income countries. The crucial determinants for successful treatment lie in the timing …

Background: The increasing reports on emerging/re-emerging arboviral disease outbreaks
or epidemics in Sub-Saharan Africa have been impacted by factors, including the changing …

En los centros de Emergencia con poco apoyo de laboratorio, es difícil diferenciar a los
pacientes con dengue grave y fiebre amarilla severa. El objetivo fue comparar el perfil …

Computer-aided drug design (CADD) is a powerful tool for the rational design of new
antivirals, allowing for the optimization of drug candidates based on their predicted …