Autophagy is a catabolic process aimed at recycling cellular components and damaged
organelles in response to diverse conditions of stress, such as nutrient deprivation, viral …

Abstract S-nitrosoglutathione reductase (GSNOR), or ADH5, is an enzyme in the alcohol
dehydrogenase (ADH) family. It is unique when compared to other ADH enzymes in that …

S-nitrosylation, a prototypic redox-based posttranslational modification, is frequently
dysregulated in disease. S-nitrosoglutathione reductase (GSNOR) regulates protein S …

BACKGROUND: The cardiac-protective role of GSNOR (S-nitrosoglutathione reductase) in
the cytoplasm, as a denitrosylase enzyme of S-nitrosylation, has been reported in cardiac …

Significance: Macrophages are crucial for tissue homeostasis. Based on their activation,
they might display classical/M1 or alternative/M2 phenotypes. M1 macrophages produce pro …

Background Cancer cachexia is characterized by muscle depletion and exercise intolerance
caused by an imbalance between protein synthesis and degradation and by impaired …

The denitrosylase S‐nitrosoglutathione reductase (GSNOR) has been suggested to sustain
mitochondrial removal by autophagy (mitophagy), functionally linking S‐nitrosylation to cell …

Melatonin and several of its metabolites are interfering with reactive nitrogen. With the notion
of prevailing melatonin formation in tissues that exceeds by far the quantities in blood …

Obesity is associated with elevated intracellular nitric oxide (NO) production, which
promotes nitrosative stress in metabolic tissues such as liver and skeletal muscle …

S-nitrosoglutathione reductase (GSNOR) represents the best-documented denitrosylase
implicated in regulating the levels of proteins posttranslationally modified by nitric oxide on …