Plasmodium vivax infections of Duffy-negative erythrocytes: historically undetected or a recent adaptation?

K Gunalan, A Niangaly, MA Thera, OK Doumbo… - Trends in …, 2018 - cell.com
Plasmodium vivax is the main cause of malarial disease in Asia and South America.
Plasmodium vivax infection was thought to be absent in African populations who are Duffy …

Molecular and cellular interactions defining the tropism of Plasmodium vivax for reticulocytes

U Kanjee, GW Rangel, MA Clark… - Current opinion in …, 2018 - Elsevier
Highlights•P. vivax has multiple and novel invasion ligand families (PvDBPs, PvRBPs,
PvTRAgs).•PvDBP binds to DARC.•PvRBP2b binds to the reticulocyte-tropic transferrin …

Comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites

SA Fraschka, M Filarsky, R Hoo, I Niederwieser… - Cell host & …, 2018 - cell.com
Heterochromatin-dependent gene silencing is central to the adaptation and survival of
Plasmodium falciparum malaria parasites, allowing clonally variant gene expression during …

The structure of a Plasmodium vivax Tryptophan Rich Antigen domain suggests a lipid binding function for a pan-Plasmodium multi-gene family

P Kundu, D Naskar, SJ McKie, S Dass… - Nature …, 2023 - nature.com
Abstract Tryptophan Rich Antigens (TRAgs) are encoded by a multi-gene family found in all
Plasmodium species, but are significantly expanded in P. vivax and closely related …

Molecular epidemiology of Plasmodium vivax and Plasmodium falciparum malaria among Duffy-positive and Duffy-negative populations in Ethiopia

E Lo, D Yewhalaw, D Zhong, E Zemene, T Degefa… - Malaria journal, 2015 - Springer
Background Malaria is the most prevalent communicable disease in Ethiopia, with 75% of
the country's landmass classified as endemic for malaria. Accurate information on the …

[HTML][HTML] Contrasting epidemiology and genetic variation of Plasmodium vivax infecting Duffy-negative individuals across Africa

E Lo, G Russo, K Pestana, D Kepple… - International Journal of …, 2021 - Elsevier
Objectives Plasmodium vivax malaria was thought to be rare in Africans who lack the Duffy
blood group antigen expression. However, recent studies indicate that P. vivax can infect …

Band 3–mediated Plasmodium vivax invasion is associated with transcriptional variation in PvTRAg genes

K De Meulenaere, SK Prajapati, E Villasis… - Frontiers in cellular …, 2022 - frontiersin.org
The Plasmodium vivax reticulocyte invasion process is still poorly understood, with only a
few receptor-ligand interactions identified to date. Individuals with the Southeast Asian …

Cerebral Malaria Is Regulated by Host-Mediated Changes in Plasmodium Gene Expression

CK Cimperman, M Pena, SM Gokcek, BP Theall… - MBio, 2023 - Am Soc Microbiol
Cerebral malaria (CM), the deadliest complication of Plasmodium infection, is a complex
and unpredictable disease. However, our understanding of the host and parasite factors that …

Transcriptome profiling of Plasmodium vivax in Saimiri monkeys identifies potential ligands for invasion

K Gunalan, JM Sá, RR Moraes Barros… - Proceedings of the …, 2019 - National Acad Sciences
Unlike the case in Asia and Latin America, Plasmodium vivax infections are rare in sub-
Saharan Africa due to the absence of the Duffy blood group antigen (Duffy antigen), the only …

Interaction of Plasmodium vivax tryptophan-rich antigen PvTRAg38 with band 3 on human erythrocyte surface facilitates parasite growth

MS Alam, V Choudhary, M Zeeshan, RK Tyagi… - Journal of Biological …, 2015 - ASBMB
Plasmodium tryptophan-rich proteins are involved in host-parasite interaction and thus
potential drug/vaccine targets. Recently, we have described several P. vivax tryptophan-rich …