The extracellular matrix (ECM) is synthesized and secreted by embryonic cells beginning at
the earliest stages of development. Our understanding of ECM composition, structure and …

The healing of an adult skin wound is a complex process requiring the collaborative efforts
of many different tissues and cell lineages. The behavior of each of the contributing cell …

The term matricellular proteins describes a family of structurally unrelated extracellular
macromolecules that, unlike structural matrix proteins, do not play a primary role in tissue …

The factors responsible for maintaining persistent organ fibrosis in systemic sclerosis (SSc)
are not known but emerging evidence implicates toll-like receptors (TLRs) in the …

The extracellular matrix molecule tenascin-C is highly expressed during embryonic
development, tissue repair and in pathological situations such as chronic inflammation and …

The determination of animal form depends on the coordination of events that lead to the
morphological patterning of cells. This epigenetic view of development suggests that …

Tenascin-C is a large, multimodular, extracellular matrix glycoprotein that exhibits a very
restricted pattern of expression but an enormously diverse range of functions. Here, we …

The basic concept, that specialized extracellular matrices rich in hyaluronan, chondroitin
sulfate proteoglycans (aggrecan, versican, neurocan, brevican, phosphacan), link proteins …

Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently
expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different …

Versican belongs to the family of the large aggregating chondroitin sulfate proteoglycans
located primarily within the extracellular matrix (ECM). Versican, like other members of its …