Eukaryotic cells engage in autophagy, an internal process of self-degradation through
lysosomes. Autophagy can be classified as selective or non-selective depending on the way …

Membranes are mainly composed of a lipid bilayer and proteins, constituting a checkpoint
for the entry and passage of signals and other molecules. Their composition can be …

The development of temozolomide (TMZ) resistance in glioma leads to poor patient
prognosis. Sorafenib, a novel diaryl urea compound and multikinase inhibitor, has the ability …

Using a cytotoxicity-based phenotypic screen of a highly diverse library of 20,000 small-
molecule compounds, we identified a quinolin-8-yl-nicotinamide, QN519, as a promising …

Autophagy is an innate cellular process characterized by self-digestion, wherein cells
degrade or recycle aged proteins, misfolded proteins, and damaged organelles via …

Dear Editor, Triple-negative breast cancer (TNBC) accounts for 20% of all breast carcinomas
and lacks a validated targeted therapy; thus, currently, cytotoxic chemotherapy is the …

Background Glioblastoma multiforme (GBM) is the most malignant adult brain tumor. Current
standard of care treatments have very limited efficacy, being the patients´ overall survival 14 …

Figura I1. 1. Esquema representativo de las proteínas RAS, 23 Figura I1. 2. Estados de
activación y regulación de las GTPasas RAS, 24 Figura I1. 3. La superfamilia RAS se divide …

Breast cancer (BCa) remains the leading cause of cancer-related deaths in women
worldwide. While the outlook for BCa patients has improved greatly over the past few years …

Ovarian cancer is a common gynaecologic malignancy that poses a serious threat to the
health and lives of women. Ursolic acid (UA) is present in various fruits, and several …