Revisiting the Crabtree/Warburg effect in a dynamic perspective: a fitness advantage against sugar-induced cell death
E de Alteriis, F Cartenì, P Parascandola, J Serpa… - Cell Cycle, 2018 - Taylor & Francis
The mechanisms behind the Warburg effect in mammalian cells, as well as for the similar
Crabtree effect in the yeast Saccharomyces cerevisiae, are still a matter of debate: why do …
Crabtree effect in the yeast Saccharomyces cerevisiae, are still a matter of debate: why do …
Cancer-associated fibroblasts drive glycolysis in a targetable signaling loop implicated in head and neck squamous cell carcinoma progression
Despite aggressive therapies, head and neck squamous cell carcinoma (HNSCC) is
associated with a less than 50% 5-year survival rate. Late-stage HNSCC frequently consists …
associated with a less than 50% 5-year survival rate. Late-stage HNSCC frequently consists …
Metabolic remodeling as a way of adapting to tumor microenvironment (TME), a job of several holders
J Serpa - Tumor Microenvironment: The Main Driver of Metabolic …, 2020 - Springer
The microenvironment depends and generates dependence on all the cells and structures
that share the same niche, the biotope. The contemporaneous view of the tumor …
that share the same niche, the biotope. The contemporaneous view of the tumor …
[HTML][HTML] BRD9 status is a major contributor for cysteine metabolic remodeling through MST and EAAT3 modulation in malignant melanoma
A Hipólito, R Xavier, C Brito, A Tomás, I Lemos… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Cutaneous melanoma (CM) is the most aggressive skin cancer, showing globally increasing
incidence. Hereditary CM accounts for a significant percentage (5–15%) of all CM cases …
incidence. Hereditary CM accounts for a significant percentage (5–15%) of all CM cases …
[HTML][HTML] NSCLC presents metabolic heterogeneity, and there is still some leeway for EGF stimuli in EGFR-mutated NSCLC
C Mendes, I Lemos, I Francisco, T Almodôvar, F Cunha… - Lung Cancer, 2023 - Elsevier
Background Metabolic remodeling is crucial in carcinogenesis and cancer progression.
Oncogenic mutations may promote metabolic reprogramming in cancer cells to support their …
Oncogenic mutations may promote metabolic reprogramming in cancer cells to support their …
Tumor-derived exosome-educated hepatic stellate cells regulate lactate metabolism of hypoxic colorectal tumor cells via the IL-6/STAT3 pathway to confer drug …
F Li, L Zhan, Q Dong, Q Wang, Y Wang, X Li… - OncoTargets and …, 2020 - Taylor & Francis
Purpose Colorectal cancer cells spread to the liver and crosstalk with the microenvironment,
and hepatic stellate cells (HSCs) are the major stromal components in the liver. However …
and hepatic stellate cells (HSCs) are the major stromal components in the liver. However …
[HTML][HTML] The mechanisms involved in miR-9 regulated apoptosis in cervical cancer by targeting FOXO3
H Zhang, Z Zhang, S Wang, S Zhang, J Bi - Biomedicine & …, 2018 - Elsevier
As a seriously global health problem, cervical cancer is a great risk to women which
threatens their lives. Approximately 30% patients who received definitive treatment may fail …
threatens their lives. Approximately 30% patients who received definitive treatment may fail …
CD147 augmented monocarboxylate transporter-1/4 expression through modulation of the Akt-FoxO3-NF-κB pathway promotes cholangiocarcinoma migration and …
P Dana, S Saisomboon, R Kariya, S Okada… - Cellular Oncology, 2020 - Springer
Purpose Cholangiocarcinoma (CCA) is an aggressive type of cancer. The major obstacles
for treatment are its late presentation and the occurrence metastases. Targeting the …
for treatment are its late presentation and the occurrence metastases. Targeting the …
[HTML][HTML] Monocarboxylate transporter 1 (MCT1), a tool to stratify acute myeloid leukemia (AML) patients and a vehicle to kill cancer cells
F Lopes-Coelho, C Nunes, S Gouveia-Fernandes… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Monocarboxylate transporter 1 (MCT1), a tool to stratify acute myeloid leukemia (AML) patients
and a vehicle to kill cancer cells - PMC Back to Top Skip to main content NIH NLM Logo Access …
and a vehicle to kill cancer cells - PMC Back to Top Skip to main content NIH NLM Logo Access …
Monocarboxylate transporter 4 regulates glioblastoma motility and monocyte binding ability
Glioblastoma (GBM) is characterized by severe hypoxic and acidic stress in an abnormal
microenvironment. Monocarboxylate transporter (MCT) 4, a pH-regulating protein, plays an …
microenvironment. Monocarboxylate transporter (MCT) 4, a pH-regulating protein, plays an …