The demonstration that dopamine loss is the key pathological feature of Parkinson's disease
(PD), and the subsequent introduction of levodopa have revolutionalized the field of PD …

The incidence and prevalence of neurodegenerative diseases (ND) increase with life
expectancy. This paper reviews the role of oxidative stress (OS) in ND and pharmacological …

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Glial cell line–derived neurotrophic factor (GDNF) and its close relative neurturin are
currently in clinical trials for neuroprotection in patients with Parkinson disease (PD) …

Midbrain dopaminergic (DA) neurons in the substantia nigra pars compacta and ventral
tegmental area regulate extrapyramidal movement and important cognitive functions …

Parkinson's disease is a common progressive neurodegenerative disease, of which the
main neuropathological hallmark is dopaminergic neuronal loss. Increased attention has …

Injury or insult to the adult nervous system often results in reactivation of signaling pathways
that are normally only active during development. The p75 neurotrophin receptor (p75 NTR) …

Parkinson's disease is a progressive neurodegenerative disorder characterized by the
degeneration of midbrain nigral dopaminergic neurons. Although its etiology remains …

High mobility group box 1 (HMGB1) is widely expressed in cells of vertebrates in two forms:
a nuclear “architectural” factor and a secreted inflammatory factor. During early brain …

The identification of the ret oncogene by Masahide Takahashi and Geoffrey Cooper in 1985
was both serendipitous and paradigmatic. By transfecting total DNA from a human …