The platinum drugs, cisplatin, carboplatin, and oxaliplatin, prevail in the treatment of cancer,
but new platinum agents have been very slow to enter the clinic. Recently, however, there …

Chemotherapy is a cornerstone of cancer therapy. Irrespective of the administered drug, it is
crucial that adequate drug amounts reach all cancer cells. To achieve this, drugs first need …

Targeted nanomedicine holds promise to find clinical use in many medical areas.
Endothelial cells that line the luminal surface of blood vessels represent a key target for …

Polymeric micelles are one of the most promising nanovehicles for drug delivery. In addition
to amphiphilicity, various individual or synergistic noncovalent interplays including strong …

Nanotechnology has great capability in formulation, reduction of side effects, and enhancing
pharmacokinetics of chemotherapeutics by designing stable or long circulating nano …

Modern medicine has helped to a great extent to eradicate and cure several diseases of
mankind and animals. But the existence of incurable diseases like cancer, Acquired …

Encapsulation of cisplatin (CDDP) into nanoparticles (NPs) with high drug loading and
encapsulation efficiency has been difficult due to the poor solubility of CDDP. However, this …

The goal of drug delivery is to ensure that therapeutic molecules reach the intended target
organ or tissue, such that the effectiveness of the drug is maximized. The efficiency of a drug …

Classical platinum (II) anticancer agents are widely-used chemotherapeutic drugs in the
clinic against a range of cancers. However, severe systemic toxicity and drug resistance …

Cisplatin and its platinum (Pt)(II) derivatives play a key role in the fight against various
human cancers such as testicular, ovarian, head and neck, lung tumors. However, their …