Functionalizing framework nucleic‐acid‐based nanostructures for biomedical application

T Zhang, T Tian, Y Lin - Advanced Materials, 2022 - Wiley Online Library
Strategies for functionalizing diverse tetrahedral framework nucleic acids (tFNAs) have been
extensively explored since the first successful fabrication of tFNA by Turberfield. One‐pot …

The biological applications of DNA nanomaterials: current challenges and future directions

W Ma, Y Zhan, Y Zhang, C Mao, X Xie… - Signal transduction and …, 2021 - nature.com
DNA, a genetic material, has been employed in different scientific directions for various
biological applications as driven by DNA nanotechnology in the past decades, including …

[HTML][HTML] Chitosan hydrogel/3D-printed poly (ε‐caprolactone) hybrid scaffold containing synovial mesenchymal stem cells for cartilage regeneration based on …

P Li, L Fu, Z Liao, Y Peng, C Ning, C Gao, D Zhang… - Biomaterials, 2021 - Elsevier
Articular cartilage (AC) injury repair has always been a difficult problem for clinicians and
researchers. Recently, a promising therapy based on mesenchymal stem cells (MSCs) has …

DNA nanotechnology from the test tube to the cell

YJ Chen, B Groves, RA Muscat, G Seelig - Nature nanotechnology, 2015 - nature.com
Abstract The programmability of Watson–Crick base pairing, combined with a decrease in
the cost of synthesis, has made DNA a widely used material for the assembly of molecular …

DNA nanostructures: current challenges and opportunities for cellular delivery

A Lacroix, HF Sleiman - ACS nano, 2021 - ACS Publications
DNA nanotechnology has produced a wide range of self-assembled structures, offering
unmatched possibilities in terms of structural design. Because of their programmable …

A review of advanced multifunctional magnetic nanostructures for cancer diagnosis and therapy integrated into an artificial intelligence approach

B Govindan, MA Sabri, A Hai, F Banat, MA Haija - Pharmaceutics, 2023 - mdpi.com
The new era of nanomedicine offers significant opportunities for cancer diagnostics and
treatment. Magnetic nanoplatforms could be highly effective tools for cancer diagnosis and …

Framework nucleic acids as programmable carrier for transdermal drug delivery

C Wiraja, Y Zhu, DCS Lio, DC Yeo, M Xie… - Nature …, 2019 - nature.com
DNA nanostructures are promising drug carriers with their intrinsic biocompatibility,
uniformity and versatility. However, rapid serum disintegration leads to low bioavailability at …

Designer DNA nanostructures for therapeutics

S Jiang, Z Ge, S Mou, H Yan, C Fan - Chem, 2021 - cell.com
The field of structural DNA nanotechnology applies the programmability of Watson-Crick
base pairing to the construction of custom nanostructures that are prescribed by the …

An Intelligent DNA Nanorobot with in Vitro Enhanced Protein Lysosomal Degradation of HER2

W Ma, Y Zhan, Y Zhang, X Shao, X Xie, C Mao… - Nano …, 2019 - ACS Publications
DNA nanorobots have emerged as new tools for nanomedicine with the potential to
ameliorate the delivery and anticancer efficacy of various drugs. DNA nanostructures have …

Precision-guided missile-like DNA nanostructure containing warhead and guidance control for aptamer-based targeted drug delivery into cancer cells in vitro and in …

C Ouyang, S Zhang, C Xue, X Yu, H Xu… - Journal of the …, 2020 - ACS Publications
It is crucial to deliver anticancer drugs to target cells with high precision and efficiency. While
nanomaterials have been shown to enhance the delivery efficiency once they reach the …