The molecular circadian clock regulates metabolic processes within the cell, and the
alignment of these clocks between tissues is essential for the maintenance of metabolic …

This article reviews the current evidence associating gut microbiota with factors that impact
host circadian-metabolic axis, such as light/dark cycles, sleep/wake cycles, diet, and eating …

Metabolic diseases are often characterized by circadian misalignment in different tissues,
yet how altered coordination and communication among tissue clocks relate to specific …

Untargeted metabolomics, as a global approach, has already proven its great potential and
capabilities for the investigation of health and disease, as well as the wide applicability for …

Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

Background Many metabolites serve as important signalling molecules to adjust cellular
activities and functions based on nutrient availability. Links between acetyl-CoA metabolism …

Shift work, defined as work occurring outside typical daytime working hours, is associated
with an increased risk of various non‐communicable diseases, including diabetes and …

Abstract" Life is an instantaneous encounter of circulating matter and flowing energy"(Jean
Giaja, Serbian physiologist), is one of the most elegant definitions not only of life but the …

Daily rhythms in physiology significantly modulate drug pharmacokinetics and
pharmacodynamics according to the time-of-day, a finding that has led to the concept of …

Objective Acute heart failure (AHF) is associated with high mortality and morbidity.
Trimethylamine N-oxide (TMAO), a gut-derived metabolite, has reported association with …