The innate immune system has the capacity to detect 'non-self'molecules derived from
pathogens, known as pathogen-associated molecular patterns, via pattern recognition …

Inflammation is the body's response to danger. One of the first immune cell types to
encounter danger is the macrophage. Macrophages sense danger signals such as …

PTEN is a dual-specificity phosphatase that is frequently mutated in human cancer, and its
deficiency in cancer has been associated with therapy resistance and poor survival …

Pyroptosis is a proinflammatory form of cell death, mediated by membrane pore-forming
proteins called gasdermins. Gasdermin pores allow the release of the pro-inflammatory …

Inflammasome activation is exclusively involved in sensing activation of innate immunity and
inflammatory response during viral infection. Accumulating evidence suggests that the …

Objectives Wedelolactone exhibits regulatory effects on some inflammatory diseases.
However, the anti‐inflammatory mechanism of wedelolactone has not been entirely …

In both plants and animals, nucleotide-binding leucine-rich repeat (NLR) immune receptors
play critical roles in pathogen recognition and activation of innate immunity. In plants, NLRs …

Bruton tyrosine kinase (BTK) is present in a wide variety of cells and may thus have
important non–B cell functions. Here, we explored the function of this kinase in …

The dysregulation of NLRP3 inflammasome plays a critical role in pathogenesis of various
human inflammatory diseases, thus NLRP3 inflammasome activation must be tightly …

The Golgi apparatus serves as a receiving station where proteins from the endoplasmic
reticulum (ER) are further processed before being sent to other cellular compartments. In …