Chronic neuropathic pain and comorbid depression syndrome (CDS) is a major worldwide
health problem that affects the quality of life of patients and imposes a tremendous …

Pain is a multifaceted process that encompasses unpleasant sensory and emotional
experiences. The essence of the pain process is aversion, or perceived negative emotion …

The amygdala is a critical brain site for regulation of emotion-associated behaviors such as
pain and anxiety. Recent studies suggest that differential cell types and synaptic circuits …

Chronic pain conditions frequently co-occur, suggesting common risks and paths to
prevention and treatment. Previous studies have reported genetic correlations among …

The human brain is arguably the most complex “machine” to ever exist. Its detailed
functioning is yet to be fully understood, let alone modelled. Neurological processes have …

We are exposed to various external and internal threats which might hurt us. The role of
taking flexible and appropriate actions against threats is played by “the limbic system” and at …

Chronic pain is attributable to both local and systemic pathology. To investigate the latter, we
focused on genetic risk shared among 24 chronic pain conditions in the UK Biobank. We …

The brain is the most complex organ in the human body and, as such, its study entails great
challenges (methodological, theoretical, etc.). Nonetheless, there is a remarkable amount of …

In writing about undergraduate research in mathematical modeling, I draw on my 31 years
as a mathematics professor at the University of Nebraska–Lincoln, where I mentored …

Neuropathic and nociplastic pain are major causes of pain and involve brain areas such as
the central nucleus of the amygdala (CeA). Within the CeA, neurons expressing protein …