Mitochondria‐derived damage‐associated molecular patterns and inflammation in the ischemic‐reperfused heart

MK Torp, J Vaage, KO Stensløkken - Acta Physiologica, 2023 - Wiley Online Library
Cardiac cell death after myocardial infarction release endogenous structures termed
damage‐associated molecular patterns (DAMPs) that trigger the innate immune system and …

Progress on role of ion channels of cardiac fibroblasts in fibrosis

C Xing, L Bao, W Li, H Fan - Frontiers in Physiology, 2023 - frontiersin.org
Cardiac fibrosis is defined as excessive deposition of extracellular matrix (ECM) in
pathological conditions. Cardiac fibroblasts (CFs) activated by injury or inflammation …

Heterogeneous effects of fibroblast-myocyte coupling in different regions of the human atria under conditions of atrial fibrillation

J Sánchez, JF Gomez, L Martinez-Mateu… - Frontiers in …, 2019 - frontiersin.org
Background: Atrial fibrillation (AF), the most common cardiac arrhythmia, is characterized by
alteration of the action potential (AP) propagation. Under persistent AF, myocytes undergo …

CGRP derived from cardiac fibroblasts is an endogenous suppressor of cardiac fibrosis

W Li, Z Zhang, X Li, J Cai, D Li, J Du… - Cardiovascular …, 2020 - academic.oup.com
Aims Aberrant activation of cardiac fibroblasts leads to cardiac fibrosis, and evolving
evidences suggest that endogenous bioactive substances derived from cardiac fibroblasts …

CircHIPK3 regulates cardiac fibroblast proliferation, migration and phenotypic switching through the miR-152-3p/TGF-β2 axis under hypoxia

W Liu, Y Wang, Z Qiu, R Zhao, Z Liu, W Chen, J Ge… - PeerJ, 2020 - peerj.com
Background The occurrence of pathological cardiac fibrosis is attributed to tissue hypoxia.
Circular RNAs play significant regulatory roles in multiple cardiovascular diseases and are …

[HTML][HTML] Upregulation of lncRNA RMRP promotes the activation of cardiac fibroblasts by regulating miR‑613

SY Zhang, SH Huang, SX Gao… - Molecular …, 2019 - spandidos-publications.com
Long non‑coding RNAs (lncRNAs) have been reported to serve a key role in a variety of
cardiovascular diseases, including in cardiac fibrosis. The present study aimed to …

Fibroblasts and platelets: a face-to-face dialogue at the heart of cardiac fibrosis

C Dufeys, J Bodart, L Bertrand… - American Journal of …, 2024 - journals.physiology.org
Myocardial fibrosis is a feature found in most cardiac diseases and a key element
contributing to heart failure and its progression. It has therefore become a subject of …

TRPM4 non-selective cation channel in human atrial fibroblast growth

C Simard, C Magaud, R Adjlane, Q Dupas… - … -European Journal of …, 2020 - Springer
Cardiac fibroblasts play an important role in cardiac matrix turnover and are involved in
cardiac fibrosis development. Ca 2+ is a driving belt in this phenomenon. This study …

[HTML][HTML] Effects of the calcium-activated chloride channel inhibitors T16Ainh-A01 and CaCCinh-A01 on cardiac fibroblast function

X Tian, K Ma, X Wang, Y Wang, Z Guo… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Calcium-activated chloride channels (CaCCs) regulate numerous
physiological processes including cell proliferation, migration, and extracellular matrix …

Single-channel recordings of RyR1 at microsecond resolution in CMOS-suspended membranes

AJW Hartel, P Ong, I Schroeder… - Proceedings of the …, 2018 - National Acad Sciences
Single-channel recordings are widely used to explore functional properties of ion channels.
Typically, such recordings are performed at bandwidths of less than 10 kHz because of …