Conspectus Compounds containing a difluoromethylene unit have gained increasing
attention due to their utility in drug design. Classic methods for the synthesis of these …

Recent advances in photoinduced trifluoromethylation and difluoroalkylation under
photocatalysis are summarized. Most of the photoredox reactions proceed efficiently under …

Substitution by the CF3S group allows for an increase in lipophilicity and electron-
withdrawing properties along with an improvement in the bioavailability of medicinal targets; …

Currently, the chemistry of organofluorine compounds is a leading and rapidly developing
area of organic chemistry. Fluorine present in a molecule largely determines its specific …

Bromodifluoromethylphosphonium bromide was solely used as the precursor of
difluorocarbene. Herein, an unprecedented visible‐light‐induced hydrodifluoromethylation …

We have developed a novel and simple protocol for the direct incorporation of a
difluoromethyl (CF2H) group into alkenes by visible‐light‐driven photoredox catalysis. The …

Transition-metal-mediated fluoroalkylation is a hot research topic in current organofluorine
chemistry. In the past five years, due to the development of new perfluoroalkylation reagents …

The visible-light-mediated oxydifluoromethylation of olefinic amides with difluoromethyl
sulfones has been explored. This method allows for an efficient and practical synthesis of a …

Under visible-light photoredox conditions, difluoromethyltriphenylphosphonium bromide
was used as the precursor of the CF2H radical for bromodifluoromethylation of alkenes. The …

Photoredox‐catalyzed reductive difluoromethylation of electron‐deficient alkenes was
achieved in one step under tin‐free, mild and neutral conditions. This protocol affords a …