NAFLD is a spectrum of progressive liver disease that encompasses simple steatosis,
NASH, fibrosis and, ultimately, cirrhosis. NAFLD is recognized as the hepatic component of …

Non-alcoholic fatty liver disease—the most common chronic liver disease—encompasses a
histological spectrum ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) …

Nuclear receptors are transcription factors which sense changing environmental or
hormonal signals and effect transcriptional changes to regulate core life functions including …

Nonalcoholic steatohepatitis (NASH) is the main cause of chronic liver disease in the
Western world and a major health problem, owing to its close association with obesity …

Ligand-activated nuclear receptors, including peroxisome proliferator-activated receptor
alpha (PPARα), pregnane X receptor, and constitutive androstane receptor, were first …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease whose
prevalence has reached global epidemic proportions. Although the disease is relatively …

Genome-wide association studies and candidate gene studies have informed our
understanding of factors contributing to the well-recognized interindividual variation in the …

Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum that spans simple
steatosis, through nonalcoholic steatohepatitis (NASH) to fibrosis and ultimately cirrhosis …

Recent data increasingly support a complex interplay between the metabolic condition
diabetes mellitus and the pathologically defined nonalcoholic fatty liver disease (NAFLD) …

Hepatic fibrosis is the primary predictor of mortality in patients with non-alcoholic
steatohepatitis (NASH). In this process, the activated hepatic stellate cells (HSCs) constitute …