Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to
arise as the disease progresses. A growing body of evidence suggests that pathological …

Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
healthy and diseased brain. As a result, there is a large body of evidence that associates …

Background: Mood disorders, consisting of unipolar and bipolar depression, are complex
diseases characterized by depressed mood and anhedonia. These core symptoms are …

It has been established that regulation of chromatin structure through post-translational
modification of histone proteins, primarily histone H3 phosphorylation and acetylation, is an …

The Clinic for Special Children (CSC) has integrated biochemical and molecular methods
into a rural pediatric practice serving Old Order Amish and Mennonite (Plain) children …

Brain injury may result in the development of epilepsy, one of the most common neurological
disorders. We previously demonstrated that albumin is critical in the generation of epilepsy …

Epilepsy is a devastating condition affecting around 70 million people worldwide. Moreover,
the quality of life of people with epilepsy (PWE) is worsened by a series of comorbidities …

Brain-derived neurotrophic factor (BDNF) attracts increasing attention from both research
and clinical fields because of its important functions in the central nervous system. An …

The growth factor brain-derived neurotrophic factor (BDNF), and its receptor tropomyosin-
related kinase receptor type B (TrkB) play an active role in numerous areas of the adult …

Brain-derived neurotrophic factor (BDNF) is an important mediator of activity-dependent
functions of the nervous system and its expression is dysregulated in several …