Background Langerhans cell histiocytosis (LCH) is a group of diseases characterized by the
proliferation and accumulation of Langerhans cells. Clinical presentations of LCH vary …

Pulmonary Langerhans cell (LC) histiocytosis (PLCH) has unknown cause and is a rare
neoplastic disorder characterized by the infiltration of lungs and various organs by bone …

Histiocytosis are rare types of hematological tumors originating from dendritic cells or
macrophages. Comprehensive genomic analysis have uncovered a series of activating …

The spectrum of somatic mutations in pediatric histiocytoses and their clinical implications
are not fully characterized, especially for non‐Langerhans cell histiocytosis (‐LCH) …

Purpose We sought to investigate the effectiveness and safety of dabrafenib in children with
BRAF V600E-mutated Langerhans cell histiocytosis (LCH). Materials and Methods A …

Langerhans cell histiocytosis (LCH) is a rare neoplastic disorder characterized by
inflammatory lesions arising from the anomalous accumulation of pathogenic CD1a+ …

Histiocytoses are one of the ultimate diagnostic challenges that every physician face at least
once in his/her life. Giving their protean manifestation and differentiated therapeutic needs …

Langerhans cell histiocytosis (LCH) is a rare inflammatory neoplasia in which somatic
mutations in components of the MAPK/ERK pathway have been identified. Osseous …

In Langerhans cell histiocytosis (LCH), somatic gene mutations in the mitogen-activated
protein kinase pathway have been identified in more than 80% of cases in Western …

Background Odontogenic keratocyst (OKC) is a unique developmental odontogenic cyst that
has the potential to behave aggressively and is associated with the nevoid basal cell …