Advances in organ-on-a-chip materials and devices

BK Nahak, A Mishra, S Preetam… - ACS applied bio …, 2022 - ACS Publications
The organ-on-a-chip (OoC) paves a way for biomedical applications ranging from preclinical
to clinical translational precision. The current trends in the in vitro modeling is to reduce the …

[HTML][HTML] Photonic and magnetic materials for on-demand local drug delivery

I Armenia, CC Ayllón, BT Herrero, F Bussolari… - Advanced drug delivery …, 2022 - Elsevier
Nanomedicine has been considered a promising tool for biomedical research and clinical
practice in the 21st century because of the great impact nanomaterials could have on human …

Design and fabrication of organ-on-chips: promises and challenges

A Tajeddin, N Mustafaoglu - Micromachines, 2021 - mdpi.com
The advent of the miniaturization approach has influenced the research trends in almost all
disciplines. Bioengineering is one of the fields benefiting from the new possibilities of …

Tailoring biomaterials for biomimetic organs-on-chips

L Sun, F Bian, D Xu, Y Luo, Y Wang, Y Zhao - Materials Horizons, 2023 - pubs.rsc.org
Organs-on-chips are microengineered microfluidic living cell culture devices with
continuously perfused chambers penetrating to cells. By mimicking the biological features of …

[HTML][HTML] Emerging trends in organ-on-a-chip systems for drug screening

Y Wang, Y Gao, Y Pan, D Zhou, Y Liu, Y Yin… - … Pharmaceutica Sinica B, 2023 - Elsevier
New drug discovery is under growing pressure to satisfy the demand from a wide range of
domains, especially from the pharmaceutical industry and healthcare services. Assessment …

Microfluidic organ-on-a-chip devices for liver disease modeling in vitro

P Kanabekova, A Kadyrova, G Kulsharova - Micromachines, 2022 - mdpi.com
Mortality from liver disease conditions continues to be very high. As liver diseases manifest
and progress silently, prompt measures after diagnosis are essential in the treatment of …

Recent advances of biosensor-integrated organ-on-a-chip technologies for diagnostics and therapeutics

A Shinde, K Illath, U Kasiviswanathan… - Analytical …, 2023 - ACS Publications
Conventional preclinical evaluation implemented in 2D monolayer cultures falls short with
multiorgan interactions, while animal systems lack the specificity of the human species …

Integrated membranes within centrifugal microfluidic devices: A review

KC O'Connell, JP Landers - Lab on a Chip, 2023 - pubs.rsc.org
Centrifugal microfluidics has evolved into a sophisticated technology capable of enabling
the exploration of fundamental questions in such fields as protein analysis, environmental …

Organs-on-Chips platforms are everywhere: A zoom on biomedical investigation

M Zommiti, N Connil, A Tahrioui, A Groboillot, C Barbey… - Bioengineering, 2022 - mdpi.com
Over the decades, conventional in vitro culture systems and animal models have been used
to study physiology, nutrient or drug metabolisms including mechanical and …

Engineering complexity in human tissue models of cancer

K Ronaldson-Bouchard, I Baldassarri… - Advanced drug delivery …, 2022 - Elsevier
Major progress in the understanding and treatment of cancer have tremendously improved
our knowledge of this complex disease and improved the length and quality of patients' …