Fluoroquinolones hybrid molecules as promising antibacterial agents in the fight against antibacterial resistance
The emergence of bacterial resistance has motivated researchers to discover new
antibacterial agents. Nowadays, fluoroquinolones keep their status as one of the essential …
antibacterial agents. Nowadays, fluoroquinolones keep their status as one of the essential …
Evaluating physiochemical properties of FDA-approved orally administered drugs
TC Reese, A Devineni, T Smith, I Lalami… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Analyses of orally administered FDA-approved drugs from 1990 to 1993
enabled the identification of a set of physiochemical properties known as Lipinski's Rule of …
enabled the identification of a set of physiochemical properties known as Lipinski's Rule of …
Epicatechin is a promising novel inhibitor of SARS-CoV-2 entry by disrupting interactions between angiotensin-converting enzyme type 2 and the viral receptor …
MBS Al-Shuhaib, HO Hashim… - Computers in Biology and …, 2022 - Elsevier
Abstract Angiotensin-converting enzyme 2 (ACE2) is the first target of SARS-CoV-2 and a
key functional host receptor through which this virus hooks into and infects human cells. The …
key functional host receptor through which this virus hooks into and infects human cells. The …
Identification of potential biogenic chalcones against antibiotic resistant efflux pump (AcrB) via computational study
S Rathod, S Dey, S Pawar, R Dhavale… - Journal of …, 2024 - Taylor & Francis
The cases of bacterial multidrug resistance are increasing every year and becoming a
serious concern for human health. Multidrug efflux pumps are key players in the formation of …
serious concern for human health. Multidrug efflux pumps are key players in the formation of …
Theoretical prediction of gastrointestinal absorption of phytochemicals
LA Vélez, Y Delgado, Y Ferrer-Acosta… - International Journal of …, 2022 - mdpi.com
The discovery of bioactive compounds for non-invasive therapy has been the goal of
research groups focused on pharmacotherapy. Phytonutrients have always been attractive …
research groups focused on pharmacotherapy. Phytonutrients have always been attractive …
[HTML][HTML] Identifying non-nucleoside inhibitors of RNA-dependent RNA-polymerase of SARS-CoV-2 through per-residue energy decomposition-based pharmacophore …
Abstract Background and Objective The current coronavirus disease-2019 (COVID-19)
pandemic has triggered a worldwide health and economic crisis. The severe acute …
pandemic has triggered a worldwide health and economic crisis. The severe acute …
In silico prediction of novel inhibitors of SARS-CoV-2 main protease through structure-based virtual screening and molecular dynamic simulation
The unprecedented pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) is threatening global health. SARS-CoV-2 has caused severe disease with …
CoV-2) is threatening global health. SARS-CoV-2 has caused severe disease with …
Investigation of indole functionalized pyrazoles and oxadiazoles as anti-inflammatory agents: Synthesis, in-vivo, in-vitro and in-silico analysis
There are several potential side and adverse effects are found to be associated with the anti-
inflammatory drugs in clinical practice. The long-term use of these clinical agents highly …
inflammatory drugs in clinical practice. The long-term use of these clinical agents highly …
Identification of potential diagnostic biomarkers and therapeutic targets for endometriosis based on bioinformatics and machine learning analysis
M Hosseini, B Hammami, M Kazemi - Journal of Assisted Reproduction …, 2023 - Springer
Abstract Purpose Endometriosis (EMs) is a major gynecological condition in women. Due to
the absence of definitive symptoms, its early detection is very challenging; thus, it is crucial …
the absence of definitive symptoms, its early detection is very challenging; thus, it is crucial …
Repositioning of anti-dengue compounds against SARS-CoV-2 as viral polyprotein processing inhibitor
A therapy for COVID-19 (Coronavirus Disease 19) caused by Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) remains elusive due to the lack of an effective …
Syndrome Coronavirus 2 (SARS-CoV-2) remains elusive due to the lack of an effective …