Simple Summary Tumor associated macrophages (TAMs) support disease progression by
providing tumor cells cytokines and chemokines necessary for malignant growth and …

Diet, serving as a vital source of nutrients, exerts a profound influence on human health and
disease progression. Recently, dietary interventions have emerged as promising adjunctive …

Nutrient stress in the tumor microenvironment requires cancer cells to adopt adaptive
metabolic programs for survival and proliferation. Therefore, knowledge of …

Cancer cells develop multiple strategies to evade T cell-mediated killing. On one hand,
cancer cells may preferentially rely on certain amino acids for rapid growth and metastasis …

Cancer immunotherapy has become an established therapeutic paradigm in oncologic
therapy, but its therapeutic efficacy remains unsatisfactory in the majority of cancer patients …

Simple Summary Arginase 1 and 2 are drivers of multiple immunosuppressive mechanisms
and tumour-specific metabolic adaptations. Pharmacological inhibition of extracellular ARG1 …

Chronic and acute myeloid leukemia evade immune system surveillance and induce
immunosuppression by expanding proleukemic Foxp3+ regulatory T cells (Tregs). High …

The development of immune checkpoint blockade (ICB) therapies has been instrumental in
advancing the field of immunotherapy. Despite the prominence of these treatments, many …

Abstract CD71+ erythroid cells (CECs) have been recently recognized in both neonates and
cancer patients as potent immunoregulatory cells. Here, we show that in mice early-stage …

Recent advances in immunotherapy have revolutionized the treatment of cancer. The use of
adoptive cell therapies (ACT) such as those based on tumor infiltrating lymphocytes (TILs) or …