Super-enhancers complexes zoom in transcription in cancer
MT Wang, QY Chen, SJ Wang, H Xie, J Liu… - Journal of Experimental …, 2023 - Springer
Super-enhancers (SEs) consist of multiple typical enhancers enriched at high density with
transcription factors, histone-modifying enzymes and cofactors. Oncogenic SEs promote …
transcription factors, histone-modifying enzymes and cofactors. Oncogenic SEs promote …
Navigating the crowd: visualizing coordination between genome dynamics, structure, and transcription
The eukaryotic genome is hierarchically structured yet highly dynamic. Regulating
transcription in this environment demands a high level of coordination to permit many …
transcription in this environment demands a high level of coordination to permit many …
Identification and functional validation of super-enhancers in Arabidopsis thaliana
H Zhao, M Yang, J Bishop, Y Teng… - Proceedings of the …, 2022 - National Acad Sciences
Super-enhancers (SEs) are exceptionally large enhancers and are recognized to play
prominent roles in cell identity in mammalian species. We surveyed the genomic regions …
prominent roles in cell identity in mammalian species. We surveyed the genomic regions …
Mapping the evolving landscape of super-enhancers during cell differentiation
Background Super-enhancers are clusters of enhancer elements that play critical roles in
the maintenance of cell identity. Current investigations on super-enhancers are centered on …
the maintenance of cell identity. Current investigations on super-enhancers are centered on …
ALU non-B-DNA conformations, flipons, binary codes and evolution
A Herbert - Royal Society Open Science, 2020 - royalsocietypublishing.org
ALUs contribute to genetic diversity by altering DNA's linear sequence through
retrotransposition, recombination and repair. ALUs also have the potential to form alternative …
retrotransposition, recombination and repair. ALUs also have the potential to form alternative …
Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington's disease mice
Temporal dynamics and mechanisms underlying epigenetic changes in Huntington's
disease (HD), a neurodegenerative disease primarily affecting the striatum, remain unclear …
disease (HD), a neurodegenerative disease primarily affecting the striatum, remain unclear …
Probabilistic establishment of speckle-associated inter-chromosomal interactions
Inter-chromosomal interactions play a crucial role in genome organization, yet the
organizational principles remain elusive. Here, we introduce a novel computational method …
organizational principles remain elusive. Here, we introduce a novel computational method …
Integrative mapping of the dog epigenome: Reference annotation for comparative intertissue and cross-species studies
Dogs have become a valuable model in exploring multifaceted diseases and biology
relevant to human health. Despite large-scale dog genome projects producing high-quality …
relevant to human health. Despite large-scale dog genome projects producing high-quality …
Super-enhancers and their parts: from prediction efforts to pathognomonic status
AV Vasileva, MG Gladkova, GA Ashniev… - International Journal of …, 2024 - mdpi.com
Super-enhancers (SEs) are regions of the genome that play a crucial regulatory role in gene
expression by promoting large-scale transcriptional responses in various cell types and …
expression by promoting large-scale transcriptional responses in various cell types and …
Experimental validation and prediction of super-enhancers: advances and challenges
Super-enhancers (SEs) are cis-regulatory elements of the human genome that have been
widely discussed since the discovery and origin of the term. Super-enhancers have been …
widely discussed since the discovery and origin of the term. Super-enhancers have been …