To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

Chromosomal instability (CIN) is associated with many human diseases, including
neurodevelopmental or neurodegenerative conditions, age-related disorders and cancer …

Abstract SynergyFinder (https://synergyfinder. fimm. fi) is a stand-alone web-application for
interactive analysis and visualization of drug combination screening data. Since its first …

The combination of folinic acid, 5-fluorouracil, oxaliplatin and/or irinotecan (FOLFOXIRI) is
the standard of care for metastatic colorectal cancer (CRC). This strategy inhibits tumor …

Research on cell death mechanisms gets a lot of attention. This is understandable as it
underlies biology in general, as well as the insight in pathological conditions and the …

Background We propose a new approach for designing personalized treatment for
colorectal cancer (CRC) patients, by combining ex vivo organoid efficacy testing with …

Lack of relevant preclinical models that reliably recapitulate the complexity and
heterogeneity of human cancer has slowed down the development and approval of new anti …

Patient-derived organoids (PDOs) established from tissues from various tumor types gave
the foundation of ex vivo models to screen and/or validate the activity of many cancer drug …

The aim of this study was to 1) investigate the effects of 27 CYP3A4 variants on the
metabolism of osimertinib and 2) study the interactions between osimertinib and others as …

The current standard of care for colorectal cancer (CRC) is a combination of
chemotherapeutics, often supplemented with targeted biological drugs. An urgent need …