Role of fibroblasts in wound healing and tissue remodeling on Earth and in space

F Cialdai, C Risaliti, M Monici - Frontiers in bioengineering and …, 2022 - frontiersin.org
Wound healing (WH) and the role fibroblasts play in the process, as well as healing
impairment and fibroblast dysfunction, have been thoroughly reviewed by other authors. We …

Modeling the impact of microgravity at the cellular level: implications for human disease

P Bradbury, H Wu, JU Choi, AE Rowan… - Frontiers in cell and …, 2020 - frontiersin.org
A lack of gravity experienced during space flight has been shown to have profound effects
on human physiology including muscle atrophy, reductions in bone density and immune …

Role of apoptosis in wound healing and apoptosis alterations in microgravity

S Riwaldt, TJ Corydon, D Pantalone… - … in bioengineering and …, 2021 - frontiersin.org
Functioning as the outermost self-renewing protective layer of the human organism, skin
protects against a multitude of harmful biological and physical stimuli. Consisting of …

Changes in interstitial fluid flow, mass transport and the bone cell response in microgravity and normogravity

F Wei, K Flowerdew, M Kinzel, LE Perotti, J Asiatico… - Bone Research, 2022 - nature.com
In recent years, our scientific interest in spaceflight has grown exponentially and resulted in
a thriving area of research, with hundreds of astronauts spending months of their time in …

Microgravity and immune cells

H Lv, H Yang, C Jiang, J Shi… - Journal of the …, 2023 - royalsocietypublishing.org
The microgravity environment experienced during spaceflight severely impaired immune
system, making astronauts vulnerable to various diseases that seriously threaten the health …

[HTML][HTML] The impact of spaceflight and simulated microgravity on cell adhesion

X Lin, K Zhang, D Wei, Y Tian, Y Gao, Z Chen… - International Journal of …, 2020 - mdpi.com
Microgravity induces a number of significant physiological changes in the cardiovascular,
nervous, immune systems, as well as the bone tissue of astronauts. Changes in cell …

Simulated microgravity attenuates skin wound healing by inhibiting dermal fibroblast migration via F‐actin/YAP signaling pathway

Y Zhou, W Lv, X Peng, Y Cheng, Y Tu… - Journal of Cellular …, 2023 - Wiley Online Library
Skin and its cell components continuously subject to extrinsic and intrinsic mechanical
forces and are mechanical sensitive. Disturbed mechanical homeostasis may lead to …

Microgravity and space radiation inhibit autophagy in human capillary endothelial cells, through either opposite or synergistic effects on specific molecular pathways

I Barravecchia, C De Cesari, M Forcato… - Cellular and Molecular …, 2022 - Springer
Microgravity and space radiation (SR) are two highly influential factors affecting humans in
space flight (SF). Many health problems reported by astronauts derive from endothelial …

Microgravity effects on the matrisome

L Buravkova, I Larina, E Andreeva, A Grigoriev - Cells, 2021 - mdpi.com
Gravity is fundamental factor determining all processes of development and vital activity on
Earth. During evolution, a complex mechanism of response to gravity alterations was formed …

[HTML][HTML] Biomaterials for human space exploration: a review of their untapped potential

M Jemison, R Olabisi - Acta Biomaterialia, 2021 - Elsevier
As biomaterial advances make headway into lightweight radiation protection, wound healing
dressings, and microbe resistant surfaces, a relevance to human space exploration …