Covalent attachment of small ubiquitin-like modifier (SUMO) to proteins is highly dynamic,
and both SUMO–protein conjugation and cleavage can be regulated. Protein desumoylation …

Proteins of the small ubiquitin-related modifier (SUMO) family are conjugated to proteins to
regulate such cellular processes as nuclear transport, transcription, chromosome …

Abstract The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in the
regulation of cell proliferation and metastasis formation and is upregulated in multiple …

Small ubiquitin-like modifiers (SUMOs) regulate a variety of cellular processes through two
distinct mechanisms, including covalent sumoylation and non-covalent SUMO interaction …

A decade has passed since SUMO (small ubiquitin-related modifier) was discovered to be a
reversible post-translational protein modifier. During this time many enzymes that participate …

The post-translational modification SUMOylation is a major regulator of protein function that
plays an important role in a wide range of cellular processes. SUMOylation involves the …

Following the discovery of protein modification by the small, highly conserved ubiquitin
polypeptide, a number of distinct ubiquitin-like proteins (Ubls) have been found to function …

Ubiquitin-binding domains (UBDs) are a collection of modular protein domains that non-
covalently bind to ubiquitin. These recently discovered motifs interpret and transmit …

PML nuclear bodies (NBs) are nuclear structures that have been implicated in processes
such as transcriptional regulation, genome stability, response to viral infection, apoptosis …

Covalent posttranslational modification with SUMO (small ubiquitin-related modifier)
modulates functions of a wide range of proteins in eukaryotic cells. Sumoylation affects the …