Piano stool Ru (II)-arene complexes having three monodentate legs: A comprehensive review on their development as anticancer therapeutics over the past decade

S Swaminathan, J Haribabu, N Balakrishnan… - Coordination chemistry …, 2022 - Elsevier
The popularity of RAPTA-C in in vivo studies has steered the way for complexes of the type
[Ru (η 6-arene)(X)(Y)(Z)] n+ (where X, Y and Z are monodentate ligands) to be developed …

An overview on the anticancer activity of Ru (II)/acylthiourea complexes

GH Ribeiro, AR Costa, AR de Souza… - Coordination Chemistry …, 2023 - Elsevier
This review outlines research on the development of ruthenium complexes containing
acylthiourea ligands with potential antitumor activity, which have been leveraged in recent …

Ru(II)-p-Cymene Complexes of Furoylthiourea Ligands for Anticancer Applications against Breast Cancer Cells

DP Dorairaj, J Haribabu, M Dharmasivam… - Inorganic …, 2023 - ACS Publications
Half-sandwich Ru (II) complexes containing nitro-substituted furoylthiourea ligands, bearing
the general formula [(η 6-p-cymene) RuCl2 (L)](1–6) and [(η 6-p-cymene) RuCl …

Coordination behavior of acylthiourea ligands in their Ru (II)–benzene complexes─ structures and anticancer activity

S Swaminathan, J Haribabu… - …, 2022 - ACS Publications
Acylthiourea ligands have applications in both synthetic and applied chemistry. The skeleton
of the ligand contains several heteroatoms which offer variable coordination modes in their …

Hinged Bipodal Furoylthiourea-Based Ru(II)-Arene Complexes: Effect of (ortho, meta, or para)-Substitution on Coordination and Anticancer Activity

S Swaminathan, J Haribabu, M Dharmasivam… - Inorganic …, 2023 - ACS Publications
We set out to design and synthesize bipodal ligands with the phenyl group as the spacer
and varied the substitution on the spacer between ortho (L1), meta (L2), and para (L3). The …

Design, synthesis, X-ray crystal structures, anticancer, DNA binding, and molecular modelling studies of pyrazole–pyrazoline hybrid derivatives

M Rana, H Hungyo, P Parashar, S Ahmad… - RSC …, 2023 - pubs.rsc.org
We have designed and synthesized three pyrazole analogs (4, 5a, 5b), pyrazole-based
chalcones (6a–6d) and (8a–8h), and N-formyl/acetyl 1, 3, 5-trisubstituted pyrazoline analogs …

Platinum group metal (PGM) complexes having acylthiourea ligand system as catalysts or anticancer agents

S Swaminathan, P Jerome, RJ Deepak… - Coordination Chemistry …, 2024 - Elsevier
The intention behind the design of a metal complex is quite crucial for its development
towards a particular application. Transition metal complexes have tremendously become …

Water-soluble mono-and binuclear Ru (η6-p-cymene) complexes containing indole thiosemicarbazones: synthesis, DFT modeling, biomolecular interactions, and in …

J Haribabu, G Sabapathi, MM Tamizh… - …, 2018 - ACS Publications
Indole thiosemicarbazone ligands were prepared from indole-3-carboxaldehyde and N-(un)
substituted thiosemicarbazide. The Ru (η6-p-cymene) complexes [Ru (η6-p-cymene)(HL1) …

Nickel (II) bis (isatin thiosemicarbazone) complexes induced apoptosis through mitochondrial signaling pathway and G0/G1 cell cycle arrest in IM-9 cells

C Balachandran, J Haribabu, K Jeyalakshmi… - Journal of Inorganic …, 2018 - Elsevier
Abstract Three novel complexes (1, 3 and 4) ligating N-substituted isatin thiosemicarbazone
derivatives have been synthesized and their structural and biological characteristics have …

Half sandwich Ru (II)-acylthiourea complexes: DNA/HSA-binding, anti-migration and cell death in a human breast tumor cell line

L Colina-Vegas, L Luna-Dulcey, AM Plutín… - Dalton …, 2017 - pubs.rsc.org
Organometallic ruthenium complexes as potential anticancer agents have been explored
due to their suitable properties, such as stability in the solid state and in solution, water …