Lipids are essential cellular components forming membranes, serving as energy reserves,
and acting as chemical messengers. Dysfunction in lipid metabolism and signaling is …

Understanding drug fingerprints in complex biological samples is essential for the
development of a drug. Hyperspectral coherent anti-Stokes Raman scattering (HS-CARS) …

Proinflammatory hepatic macrophage activation plays a key role in the development of
nonalcoholic steatohepatitis (NASH). This involves increased embryonic hepatic Kupffer cell …

Our understanding of HIV infection has greatly advanced since the discovery of the virus in
1983. Treatment options have improved the quality of life of people living with HIV/AIDS …

Antisense oligonucleotide (ASO)-based therapeutics hold great potential for the treatment of
a variety of diseases. Therefore, a better understanding of cellular delivery, uptake, and …

Current methods for detecting unlabeled antisense oligonucleotide (ASO) drugs rely on
immunohistochemistry (IHC) and/or conjugated molecules, which lack sufficient sensitivity …

A liver-on-a-chip model is an advanced complex in vitro model (CIVM) that incorporates
different cell types and extracellular matrix to mimic the microenvironment of the human liver …

High-content screening (HCS) and high-throughput screening (HTS) are common processes
used in biological research and drug discovery. They allow rapid examination of thousands …

The current regulatory landscape for the development of oligonucleotide drugs may lead
companies to perform a variety of small molecule-focussed absorption, distribution …

Antisense oligonucleotides (ASOs) represent a powerful therapeutic modality that can
selectively modulate gene expression. However, ASOs face two major hurdles that restrict …