Since Anfinsen demonstrated that the information encoded in a protein's amino acid
sequence determines its structure in 1973, solving the protein structure prediction problem …

Many molecular biosystems and biomedical systems belong to the multi-label systems in
which each of their constituent molecules possesses one or more than one function or …

Exploiting sequence–structure–function relationships in biotechnology requires improved
methods for aligning proteins that have low sequence similarity to previously annotated …

During its first two and a half months, the recently emerged 2019 novel coronavirus, SARS-
CoV-2, has already infected over one-hundred thousand people worldwide and has taken …

Bioactive small molecules, such as drugs or metabolites, bind to proteins or other macro-
molecular targets to modulate their activity, which in turn results in the observed phenotypic …

Detection of protein homology via sequence similarity has important applications in biology,
from protein structure and function prediction to reconstruction of phylogenies. Although …

Sequence alignment is a long standing problem in bioinformatics. The Basic Local
Alignment Search Tool (BLAST) is one of the most popular and fundamental alignment tools …

Protein function annotation has been one of the longstanding issues in biological sciences,
and various computational methods have been developed. However, the existing methods …

One of the fundamental goals in proteomics and cell biology is to identify the functions of
proteins in various cellular organelles and pathways. Information of subcellular locations of …

Prediction of protein subcellular localization is a challenging problem, particularly when the
system concerned contains both singleplex and multiplex proteins. In this paper, by …