Endogenous retroelements and the viral mimicry response in cancer therapy and cellular homeostasis
Features of the cancer epigenome distinguish cancers from their respective cell of origin and
establish therapeutic vulnerabilities that can be exploited through pharmacologic inhibition …
establish therapeutic vulnerabilities that can be exploited through pharmacologic inhibition …
Epigenomic reprogramming as a driver of malignant glioma
RE Phillips, AA Soshnev, CD Allis - Cancer cell, 2020 - cell.com
Malignant gliomas are central nervous system tumors and remain among the most treatment-
resistant cancers. Exome sequencing has revealed significant heterogeneity and important …
resistant cancers. Exome sequencing has revealed significant heterogeneity and important …
Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways
Abstract Patients with H3K27M-mutant diffuse midline glioma (DMG) have no proven
effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the …
effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the …
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas
Abstract Canonical (H3. 1/H3. 2) and noncanonical (H3. 3) histone 3 K27M-mutant gliomas
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …
Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency
Cancer therapies that target epigenetic repressors can mediate their effects by activating
retroelements within the human genome. Retroelement transcripts can form double …
retroelements within the human genome. Retroelement transcripts can form double …
[HTML][HTML] Histone H3. 3G34-mutant interneuron progenitors co-opt PDGFRA for gliomagenesis
Summary Histone H3. 3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly
gliomas and show exquisite regional and temporal specificity, suggesting a developmental …
gliomas and show exquisite regional and temporal specificity, suggesting a developmental …
[HTML][HTML] Integrated metabolic and epigenomic reprograming by H3K27M mutations in diffuse intrinsic pontine gliomas
Summary H3K27M diffuse intrinsic pontine gliomas (DIPGs) are fatal and lack treatments.
They mainly harbor H3. 3K27M mutations resulting in H3K27me3 reduction. Integrated …
They mainly harbor H3. 3K27M mutations resulting in H3K27me3 reduction. Integrated …
Stalled developmental programs at the root of pediatric brain tumors
Childhood brain tumors have suspected prenatal origins. To identify vulnerable
developmental states, we generated a single-cell transcriptome atlas of> 65,000 cells from …
developmental states, we generated a single-cell transcriptome atlas of> 65,000 cells from …
H3 K27M and EZHIP impede H3K27-methylation spreading by inhibiting allosterically stimulated PRC2
SU Jain, AQ Rashoff, SD Krabbenhoft, D Hoelper… - Molecular Cell, 2020 - cell.com
Diffuse midline gliomas and posterior fossa type A ependymomas contain the recurrent
histone H3 lysine 27 (H3 K27M) mutation and express the H3 K27M-mimic EZHIP (CXorf67) …
histone H3 lysine 27 (H3 K27M) mutation and express the H3 K27M-mimic EZHIP (CXorf67) …
Histone variant and cell context determine H3K27M reprogramming of the enhancer landscape and oncogenic state
S Nagaraja, MA Quezada, SM Gillespie, M Arzt… - Molecular cell, 2019 - cell.com
Development of effective targeted cancer therapies is fundamentally limited by our
molecular understanding of disease pathogenesis. Diffuse intrinsic pontine glioma (DIPG) is …
molecular understanding of disease pathogenesis. Diffuse intrinsic pontine glioma (DIPG) is …