Red blood cells (RBCs), which constitute the most abundant cell type in the body, come in
two distinct flavors-primitive and definitive. Definitive RBCs in mammals circulate as smaller …

Adult-repopulating hematopoietic stem cells (HSCs) emerge in low numbers in the
midgestation mouse embryo from a subset of arterial endothelium, through an endothelial-to …

Apoptosis is a process of programmed cell death which has an important role in tissue
homeostasis and in the control of organism development. Here, we focus on information …

Megakaryocyte (MK) development in the bone marrow progresses spatially from the
endosteal niche, which promotes MK progenitor proliferation, to the sinusoidal vascular …

Primitive erythroid cells, the first red blood cells produced in the mammalian embryo, are
necessary for embryonic survival. Erythropoietin and its receptor EpoR, are absolutely …

Purpose In a nuclear or radiological event, an early diagnostic tool is needed to distinguish
the worried well from those individuals who may later develop life-threatenFing hematologic …

Erythropoiesis is a robust process of cellular expansion and maturation occurring in murine
bone marrow and spleen. We previously determined that sublethal irradiation, unlike …

Abstract Nuclear factor (erythroid-derived 2) like 2 (Nrf2) is a key regulator in protecting cells
against stress by targeting many anti-stress response genes. Recent evidence also reveals …

Radiation therapy is widely used as a treatment tool for malignancies. However, radiation-
related complications are still unavoidable risks for off-target cells. Little is known about …

Erythroid cell maturation and diseases affecting erythrocytes are frequently accompanied by
morphologic and immunophenotypic changes to these cells. In the past, these changes …