Endocannabinoids acting via CB 1 receptors (CB 1 R) play a critical role in regulating
energy homeostasis, which was the rationale for the pharmaceutical development of CB 1 R …

Neonatal encephalopathy is a leading cause of morbidity and mortality worldwide. Although
therapeutic hypothermia (HT) is now standard practice in most neonatal intensive care units …

Nephrotoxicity is a major side effect for the antineoplastic drug cisplatin. Here, we employed
pharmacological, biochemical, and molecular studies to investigate the role of peroxisome …

Upregulation of inducible nitric oxide synthase (iNOS) has been reported in both
experimental and clinical hypertension. However, although pro‐inflammatory cytokines that …

In addition to insulin sensitization, the thiazolidenedione drug pioglitazone exhibits
favorable circulatory effects. Here, we hypothesized that pioglitazone protects against the …

Aim: To examine whether iNOS contributes to endothelial dysfunction in aged rats. Methods:
Male Sprague Dawley rats were divided into three groups: young rats, aged rats treated with …

Abstract γ-Aminobutyric acid (GABA), the principal brain inhibitory neurotransmitter,
modulates inflammatory and neurodegenerative disease. Here, we tested the hypothesis …

Nucleoredoxin (NXN) is a redox-regulating protein potentially targeted by reactive oxygen
species (ROS). It regulates molecular pathways that participate in several key cellular …

Our previous studies showed that ethanol elicited estrogen (E 2)-dependent myocardial
oxidative stress and dysfunction. In the present study we tested the hypothesis that E 2 …

Evidence suggests that male rats are protected against the hypotensive and myocardial
depressant effects of ethanol compared with females. We investigated whether E 2 modifies …