An increase in pulsatile release of LHRH is essential for the onset of puberty. However, the
mechanism controlling the pubertal increase in LHRH release is still unclear. In primates the …

During periods of metabolic stress, animals must channel energy toward survival and away
from processes such as reproduction. The reproductive axis, therefore, has the capacity to …

Ovulatory disorders are the most common clinical feature exhibited among obese women.
Initiation of ovulation physiologically requires a surge of gonadotropin-releasing hormone …

Bioactive peptides (ie, neuropeptides or peptide hormones) represent the largest class of
cell-cell signaling molecules in metazoans and are potent regulators of neural and …

Eight experiments supported the hypotheses that reflexive testosterone release by male
mice during sexual encounters reduces male anxiety (operationally defined in terms of …

The neuropeptide kisspeptin is necessary for reproduction, fertility, and puberty. Here, we
show strong kisspeptin innervation of hypothalamic anorexigenic proopiomelanocortin …

Living organisms represent, in essence, dynamic interactions of high complexity between
membrane‐separated compartments that cannot exist on their own, but reach behaviour in …

The absolute requirement for reproduction implies that the hypothalamo-pituitary-gonadal
axis, controlling fertility, is an evolutionary robust mechanism. The GnRH neurons of the …

The pattern of regular ovulatory cycles required for normal reproduction in women is
achieved through precise functional and temporal integration of stimulatory and inhibitory …

Fertility is gated by nutrition and the availability of stored energy reserves, but the cellular
and molecular mechanisms that link energy stores and reproduction are not well …