Molecular mechanisms of fast neurotransmitter release
AT Brunger, UB Choi, Y Lai, J Leitz… - Annual review of …, 2018 - annualreviews.org
This review summarizes current knowledge of synaptic proteins that are central to synaptic
vesicle fusion in presynaptic active zones, including SNAREs (s oluble N-ethylmaleimide …
vesicle fusion in presynaptic active zones, including SNAREs (s oluble N-ethylmaleimide …
Vesicle trafficking and vesicle fusion: mechanisms, biological functions, and their implications for potential disease therapy
L Cui, H Li, Y Xi, Q Hu, H Liu, J Fan, Y Xiang… - Molecular …, 2022 - Springer
Intracellular vesicle trafficking is the fundamental process to maintain the homeostasis of
membrane-enclosed organelles in eukaryotic cells. These organelles transport cargo from …
membrane-enclosed organelles in eukaryotic cells. These organelles transport cargo from …
Synaptotagmin 7 is targeted to the axonal plasma membrane through γ-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons
Abstract Synaptotagmin 7 (SYT7) has emerged as a key regulator of presynaptic function,
but its localization and precise role in the synaptic vesicle cycle remain the subject of …
but its localization and precise role in the synaptic vesicle cycle remain the subject of …
Molecular basis for synaptotagmin-1-associated neurodevelopmental disorder
Summary At neuronal synapses, synaptotagmin-1 (syt1) acts as a Ca 2+ sensor that
synchronizes neurotransmitter release with Ca 2+ influx during action potential firing …
synchronizes neurotransmitter release with Ca 2+ influx during action potential firing …
Synaptotagmin 1 oligomerization via the juxtamembrane linker regulates spontaneous and evoked neurotransmitter release
Synaptotagmin 1 (syt1) is a Ca2+ sensor that regulates synaptic vesicle exocytosis. Cell-
based experiments suggest that syt1 functions as a multimer; however, biochemical and …
based experiments suggest that syt1 functions as a multimer; however, biochemical and …
Resolving kinetic intermediates during the regulated assembly and disassembly of fusion pores
The opening of a fusion pore during exocytosis creates the first aqueous connection
between the lumen of a vesicle and the extracellular space. Soluble N-ethylmaleimide …
between the lumen of a vesicle and the extracellular space. Soluble N-ethylmaleimide …
Single-molecule force spectroscopy of protein-membrane interactions
L Ma, Y Cai, Y Li, J Jiao, Z Wu, B O'Shaughnessy… - Elife, 2017 - elifesciences.org
Many biological processes rely on protein–membrane interactions in the presence of
mechanical forces, yet high resolution methods to quantify such interactions are lacking …
mechanical forces, yet high resolution methods to quantify such interactions are lacking …
The juxtamembrane linker of synaptotagmin 1 regulates Ca2+ binding via liquid-liquid phase separation
Abstract Synaptotagmin (syt) 1, a Ca2+ sensor for synaptic vesicle exocytosis, functions in
vivo as a multimer. Syt1 senses Ca2+ via tandem C2-domains that are connected to a single …
vivo as a multimer. Syt1 senses Ca2+ via tandem C2-domains that are connected to a single …
Synaptotagmin 2 is the fast Ca2+ sensor at a central inhibitory synapse
GABAergic synapses in brain circuits generate inhibitory output signals with submillisecond
latency and temporal precision. Whether the molecular identity of the release sensor …
latency and temporal precision. Whether the molecular identity of the release sensor …
Calcium sensitive ring-like oligomers formed by synaptotagmin
J Wang, O Bello, SM Auclair, J Wang… - Proceedings of the …, 2014 - National Acad Sciences
The synaptic vesicle protein synaptotagmin-1 (SYT) is required to couple calcium influx to
the membrane fusion machinery. However, the structural mechanism underlying this …
the membrane fusion machinery. However, the structural mechanism underlying this …