Localization and functional roles of components of the translation apparatus in the eukaryotic cell nucleus

ZM Kachaev, SD Ivashchenko, EN Kozlov… - Cells, 2021 - mdpi.com
Components of the translation apparatus, including ribosomal proteins, have been found in
cell nuclei in various organisms. Components of the translation apparatus are involved in …

Genomic and functional insights into the diversification of the elongation factor eEF1Bγ in fungi

J Renou, R Sormani, E Gelhaye, C Didierjean… - Fungal Biology …, 2022 - Elsevier
Abstract eEF1Bγs are proteins found in all eukaryotes and have a role in protein translation,
being part of the nucleotide exchange factor eEF1B of the elongation factor complex 1. They …

[HTML][HTML] The eEF1 family of mammalian translation elongation factors

BS Negrutskii, VF Shalak, OV Novosylna, LV Porubleva… - BBA advances, 2023 - Elsevier
The eEF1 family of mammalian translation elongation factors is comprised of the two
variants of eEF1A (eEF1A1 and eEF1A2), and the eEF1B complex. The latter consists of …

[HTML][HTML] eEF1A1 overexpression enhances tumor progression and indicates poor prognosis in hepatocellular carcinoma

SL Chen, SX Lu, LL Liu, CH Wang, X Yang… - Translational …, 2018 - Elsevier
Liver is a major contributor of protein production physiologically. The aberrant state of
protein synthesis leads to tumor progression. Eukaryotic elongation factor 1 alpha 1 …

EEF1D overexpression promotes osteosarcoma cell proliferation by facilitating Akt-mTOR and Akt-bad signaling

D Cheng, S Li, B Zhu, S Zhou, Q Yang - Journal of Experimental & Clinical …, 2018 - Springer
Background Dysregulation of eukaryotic translation elongation factor 1 delta (EEF1D) in
cancers has been reported; however, the role and mechanisms of EEF1D in osteosarcoma …

[HTML][HTML] Chaperonin containing TCP1 subunit 5 is a tumor associated antigen of non-small cell lung cancer

H Gao, M Zheng, S Sun, H Wang, Z Yue, Y Zhu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Novel tumor antigens and their related autoantibodies have tremendous potential for early
diagnosis of non-small cell lung cancer (NSCLC). In this study, we identify antigens from …

EEF1B2 regulates bone marrow-derived mesenchymal stem cells bone-fat balance via Wnt/β-catenin signaling

S Feng, Z Feng, Y Wei, X Zheng, Z Deng, Z Liao… - Cellular and Molecular …, 2024 - Springer
The pathological advancement of osteoporosis is caused by the uneven development of
bone marrow-derived mesenchymal stem cells (BMSCs) in terms of osteogenesis and …

eEF1Bγ binds the Che-1 and TP53 gene promoters and their transcripts

C Pisani, A Onori, F Gabanella… - Journal of Experimental …, 2016 - Springer
Background We have previously shown that the eukaryotic elongation factor subunit 1B
gamma (eEF1Bγ) interacts with the RNA polymerase II (pol II) alpha-like subunit …

Non-translational Connections of eEF1B in the Cytoplasm and Nucleus of Cancer Cells

B Negrutskii - Frontiers in Molecular Biosciences, 2020 - frontiersin.org
The human translation machinery includes three types of supramolecular complexes
involved in elongation of the polypeptide chain: the ribosome, complex of elongation factors …

Initiation and elongation factor co-expression correlates with recurrence and survival in epithelial ovarian cancer

M Sobočan, D Brunialti, S Sprung, C Schatz… - Journal of Ovarian …, 2022 - Springer
High grade epithelial ovarian cancer (EOC) represents a diagnostic and therapeutic
challenge due to its aggressive features and short recurrence free survival (RFS) after …