Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose catalytic activities are
regulated by interactions with cyclins and CDK inhibitors (CKIs). CDKs are key regulatory …

Cyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as
promising candidate targets for cancer treatment. These proteins complexed with cyclins …

Summary The CDK4/6 inhibitor, palbociclib (PAL), significantly improves progression-free
survival in HR+/HER2− breast cancer when combined with anti-hormonals. We sought to …

The efficacy of therapeutics is dependent on a drug binding to its cognate target.
Optimization of target engagement by drugs in cells is often challenging, because drug …

Deregulation of the cell cycle machinery, which has been linked to dysregulation of cyclin-
dependent kinases (CDKs), is a defining characteristic of cancer, eventually promoting …

Cyclin-dependent kinases (CDKs) are proteins pivotal to a wide range of cellular functions,
most importantly cell division and transcription, and their dysregulations have been …

Cyclin-dependent kinases (CDK/Cyclins) form a family of heterodimeric kinases that play
central roles in regulation of cell cycle progression, transcription and other major biological …

Cell proliferation is an essential mechanism for growth, development and regeneration of
eukaryotic organisms; however, it is also the cause of one of the most devastating diseases …

Abstract p16INK4a, located on chromosome 9p21. 3, is lost among a cluster of neighboring
tumor suppressor genes. Although it is classically known for its capacity to inhibit cyclin …

In contrast to its close homolog CDK4, the cell cycle kinase CDK6 is expressed at high
levels in lymphoid malignancies. In a model for p185 BCR-ABL+ B-acute lymphoid …