Cells respond to and actively remodel the extracellular matrix (ECM). The dynamic and
bidirectional interaction between cells and ECM, especially their mechanical interactions …

In vivo, corneal keratocytes reside within a complex 3D extracellular matrix (ECM) consisting
of highly aligned collagen lamellae, growth factors, and other extracellular matrix …

Collagen fibrils, linear arrangements of collagen monomers, 20–500 nm in diameter,
comprising hundreds of molecules in their cross-section, are the fundamental structural unit …

The optimal functionality of the native corneal stroma is mainly dependent on the well‐
ordered arrangement of extracellular matrix (ECM) and the pressurized structure. In order to …

This study utilizes high resolution multi-dimensional imaging to identify temporal and spatial
changes in cell/extracellular matrix (ECM) patterning mediating cell migration, fibrosis …

Quantifying collagen fiber architecture has clinical and scientific relevance across a variety
of tissue types and adds functionality to otherwise largely qualitative imaging modalities …

Automatic quantification and visualization of 3-D collagen fiber architecture using Optical
Coherence Tomography (OCT) has previously relied on polarization information and/or prior …

Wound healing is characterized by cell and extracellular matrix changes mediating cell
migration, fibrosis, remodeling and regeneration. We previously demonstrated that chick …

While tissue form and function is highly dependent upon tissue-specific collagen
composition and organization, little is known of the mechanisms controlling the bundling of …

Currently, there is no mechanistic model that fully explains the initial synthesis and
organization of durable animal structure. As a result, our understanding of extracellular …