The clinical significance of duration of untreated psychosis: an umbrella review and random‐effects meta‐analysis

OD Howes, T Whitehurst, E Shatalina… - World …, 2021 - Wiley Online Library
The idea that a longer duration of untreated psychosis (DUP) leads to poorer outcomes has
contributed to extensive changes in mental health services worldwide and has attracted …

Sex differences in schizophrenia relevant to clinical care

MV Seeman - Expert review of neurotherapeutics, 2021 - Taylor & Francis
Introduction: Most medical diagnoses present somewhat differently in men and women,
more so at specific periods of life. Treatment effects may also differ. This is true for …

The course of general cognitive ability in individuals with psychotic disorders

K Jonas, W Lian, J Callahan, CJ Ruggero… - JAMA …, 2022 - jamanetwork.com
Importance Schizophrenia is associated with major cognitive deficits and has been
conceptualized as both a neurodevelopmental and a neurodegenerative disorder. However …

20-year prospective, sequential follow-up study of heterogeneity in associations of duration of untreated psychosis with symptoms, functioning, and quality of life …

D O'Keeffe, A Kinsella… - American Journal of …, 2022 - Am Psychiatric Assoc
Objective: Determining the extent to which relationships between duration of untreated
psychosis (DUP) and outcome endure longitudinally across the lifetime course of psychotic …

The pharmacologic treatment of schizophrenia—2021

DC Goff - Jama, 2021 - jamanetwork.com
Schizophrenia is a chronic psychotic disorder with typical onset in early adulthood and a
lifetime prevalence of approximately 1%. In addition to the hallmark symptoms of psychosis …

Long-term outcomes of first-admission psychosis: a naturalistic 21-year follow-up study of symptomatic, functional and personal recovery and their baseline predictors

V Peralta, E García de Jalón, L Moreno-Izco… - Schizophrenia …, 2022 - academic.oup.com
This study was aimed at characterizing long-term outcomes of first-admission psychosis and
examining their baseline predictors. Participants were assessed at baseline for 38 candidate …

What is the duration of untreated psychosis worldwide?–A meta-analysis of pooled mean and median time and regional trends and other correlates across 369 …

GS de Pablo, C Aymerich, D Guinart… - Psychological …, 2024 - cambridge.org
Duration of untreated psychosis (DUP) has been associated with poor mental health
outcomes. We aimed to meta-analytically estimate the mean and median DUP worldwide …

What can psychiatrists learn from SARS and MERS outbreaks?

IE Sommer, PR Bakker - The Lancet Psychiatry, 2020 - thelancet.com
While standard care for patients with psychiatric disorders must continue during the current
COVID-19 pandemic, psychiatrists also need to treat psychiatric complications of patients …

Hippocampal volume in early psychosis: a 2-year longitudinal study

M McHugo, K Armstrong, MJ Roeske… - Translational …, 2020 - nature.com
Cross-sectional studies suggest that hippocampal volume declines across stages of
psychosis. In contrast, longitudinal studies indicate that hippocampal volume is stable in the …

Moving from risk to resilience in psychosis research

KN Thakkar, A McCleery, KS Minor, J Lee… - Nature Reviews …, 2023 - nature.com
Psychosis research has traditionally focused on vulnerability and the detrimental outcomes
of risk exposure. However, there is substantial variability in psychological and functional …