Single-cell analysis is essential to improve our understanding of cell functionality from
cellular and subcellular aspects for diagnosis and therapy. Single-cell cultivation is one of …

The investigation of human disease mechanisms is difficult due to the heterogeneity in gene
expression and the physiological state of cells in a given population. In comparison to bulk …

Controlled encapsulation and pairing of single cells within a confined 3D matrix can enable
the replication of the highly ordered cellular structure of human tissues. Microgels with …

Tumor cell migration toward and intravasation into capillaries is an early and key event in
cancer metastasis, yet not all cancer cells are imbued with the same capability to do so. This …

The endometrium is the inner lining of the uterus. Following specific cyclic hormonal
stimulation, endometrial stromal fibroblasts (stroma) and vascular endothelial cells exhibit …

Regional metastasis of head and neck cancer (HNC) is prevalent (approximately 50% of
patients at diagnosis), yet the underlying drivers and mechanisms of lymphatic spread …

Twenty percent of breast cancer (BC) patients develop distant metastasis for which there is
no cure. Mesenchymal stem/stromal cells (MSCs) in the tumor microenvironment were …

Microfluidic devices capable of manipulating and guiding small fluid volumes open new
methodical approaches in the fields of biology, pharmacy, and medicine. They have already …

Recent research suggests that cancer stem-like cells (CSCs) are the key subpopulation for
tumor relapse and metastasis. Due to cancer plasticity in surface antigen and enzymatic …

Considerable evidence points to cancer stem-like cells (CSCs) as responsible for promoting
progression, metastasis, and drug resistance. Without damage to the cell biological …