Alcoholic liver disease is the result of cascade events, which clinically first lead to alcoholic
fatty liver, and then mostly via alcoholic steatohepatitis or alcoholic hepatitis potentially to …

The γ-aminobutyric acid (GABA) type A receptor system, the main fast-acting inhibitory
neurotransmitter system in the brain, is the pharmacological target for many drugs used …

Alcohols are known modulators of lipid bilayer properties. Their biological effects have long
been attributed to their bilayer-modifying effects, but alcohols can also alter protein function …

Alcohol and nicotine are often co-abused. As many as 80–95% of alcoholics are also
smokers, suggesting that ethanol and nicotine, the primary addictive component of tobacco …

Background Alcohol use disorders result from repeated binge and chronic alcohol
consumption followed by negative effects, such as anxiety, upon cessation. This process is …

The bed nucleus of the stria terminalis (BNST) is a critical region for alcohol/drug-induced
negative affect and stress-induced reinstatement. NMDA receptor (NMDAR)-dependent …

Background: Different regions of the striatum may have distinct roles in acute intoxication,
alcohol seeking, dependence, and withdrawal. Methods: The recent advances are reviewed …

Epidemiological studies consistently find correlations between nicotine and alcohol use, yet
the neural mechanisms underlying their interaction remain largely unknown. Nicotine and …

Alcohol misuse has deleterious effects on personal health, family, societal units, and global
economies. Moreover, alcohol misuse usually leads to several diseases and conditions …

Abstract Development of effective treatments for alcohol use disorder (AUD) represents an
important public health goal. This review provides a summary of completed preclinical and …