Since their original discovery, type I interferons (IFN-Is) have been closely associated with
antiviral immune responses. However, their biological functions go far beyond this role, with …

Systemic lupus erythematosus (SLE) is a rare autoimmune/inflammatory disease with
significant morbidity and mortality. Approximately 15–20% of SLE patients develop the …

Summary Background Chronic inflammatory diseases (CIDs) are systems disorders that
affect diverse organs including the intestine, joints and skin. The essential amino acid …

Juvenile systemic lupus erythematosus (jSLE) is a complex inflammatory autoimmune
disorder. In the last decades, genetic factors and activation pathways have been …

The N-terminal domain of Three Prime Repair Exonuclease 1 (TREX1) is catalytically active
and can degrade dsDNA or ssDNA in the cytosol, whereas the C-terminal domain is …

Systemic lupus erythematosus (SLE) is a chronic immune-inflammatory disease
characterized by multiorgan affectation and lowered self-tolerance. Additionally, epigenetic …

STAT4 plays an important role in disease activity in SLE patients. STAT4 particles have the
capacity to activate the transcription of genes associated with the production of TH1 and …

One of the common cutaneous symptoms of systemic lupus erythematosus (SLE) that may
have major psychosocial effects in a female is diffuse alopecia. Although Janus kinase …

Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can
cause diverse clinical manifestations in multiple organ systems. Child-onset SLE (cSLE) is …

The progression and pathogenesis of membranous glomerulonephritis (MGN) are
inextricably linked to chronic inflammation. Despite improving clinical remission rates due to …