Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …

ABSTRACT A long-standing goal of spinal cord injury research is to develop effective spinal
cord repair strategies for the clinic. Rat models of spinal cord injury provide an important …

Reactive astrocytes are prominent in the cellular response to spinal cord injury (SCI), but
their roles are not well understood. We used a transgenic mouse model to study the …

Genetically engineered mice are used extensively to examine molecular responses to spinal
cord injury (SCI). Inherent strain differences may confound behavioral outcomes; therefore …

Signaling mechanisms that regulate astrocyte reactivity and scar formation after spinal cord
injury (SCI) are not well defined. We used the Cre recombinase (Cre)-loxP system under …

The characterization of mouse models of human disease is essential for understanding the
underlying pathophysiology and developing new therapeutics. Many diseases are often …

Axonal degeneration is a common pathological feature in many acute and chronic
neurological diseases such as spinal cord injury (SCI). SARM1 (sterile alpha and TIR motif …

Spinal contusion pathology in rats and mice is distinct. Cystic cavities form at the impact site
in rats while a dense connective tissue matrix occupies the injury site in mice. Because …

Although many therapeutic interventions have shown promise in treating spinal cord injury,
focusing on a single aspect of repair cannot achieve successful and functional regeneration …

Spinal cord injury produces prominent disruption of the blood‐spinal cord barrier. We have
defined the blood‐spinal cord barrier breakdown to the protein luciferase (61 kDa) in the …