Integrins mediate cell adhesion and transmit mechanical and chemical signals to the cell
interior. Various mechanisms deregulate integrin signaling in cancer, empowering tumor …

All solid tumours require a vascular supply in order to progress. Although the ability to
induce angiogenesis (new blood vessel growth) has long been regarded as essential to this …

Tumor growth and metastasis rely on tumor vascular network for the adequate supply of
oxygen and nutrients. Tumor angiogenesis relies on a highly complex program of growth …

Anti-angiogenic therapy is one of the promising strategies for many types of solid cancers.
Bevacizumab (Avastin), a recombinant humanized monoclonal antibody of vascular …

Wound healing is a complex process, which ultimately leads to fibrosis if not repaired well.
Pathologically very similar to fibrosis is the tumor stroma, found in several solid tumors which …

Glioblastoma (GBM) is the most aggressive and common form of primary brain cancer.
Several decades of research have provided great insight into GBM progression; however …

Fibronectin is a matrix glycoprotein which has not only been found to be over-expressed in
several cancers, but has been shown to participate in several steps of tumorigenesis. The …

Extracellular matrix (ECM) macromolecules together with a multitude of different molecules
residing in the extracellular space play a vital role in the regulation of cellular phenotype and …

Ovarian cancer (OvCa) metastasizes to organs in the abdominal cavity, such as the
omentum, which are covered by a single layer of mesothelial cells. Mesothelial cells are …

Drug-tolerant persister (DTP) cells have attracted significant interest, given their
predominant role in treatment failure. In this respect, DTP cells reportedly survive after …