Purpose To investigate the global burden of sepsis in hospitalized adults by updating and
expanding a systematic review and meta-analysis and to compare findings with recent …

Sepsis is defined as “a life-threatening organ dysfunction caused by a host's dysfunctional
response to infection”. Although the treatment of sepsis has developed rapidly in the past …

Objective: Decades-old, common ICU practices including deep sedation, immobilization,
and limited family access are being challenged. We endeavoured to evaluate the …

As a complex multicellular structure of the vascular system at the central nervous system
(CNS), the blood-brain barrier (BBB) separates the CNS from the system circulation and …

Importance Survival from sepsis has improved in recent years, resulting in an increasing
number of patients who have survived sepsis treatment. Current sepsis guidelines do not …

Importance Definitions of sepsis and septic shock were last revised in 2001. Considerable
advances have since been made into the pathobiology (changes in organ function …

Objectives: To provide an appraisal of the evolving paradigms in the pathophysiology of
sepsis and propose the evolution of a new phenotype of critically ill patients, its potential …

Severe sepsis is a leading cause of death in the United States and the most common cause
of death among critically ill patients in non-coronary intensive care units (ICU). Respiratory …

Importance The risk of cardiovascular disease (CVD) after infection is poorly understood.
Objective To determine whether hospitalization for pneumonia is associated with an …

Objectives: Trends in severe sepsis mortality derived from administrative data may be
biased by changing International Classification of Diseases, 9th Revision, Clinical …