Classically the limit to endurance of exercise is explained in terms of metabolic capacity.
Cardio-respiratory capacity and muscle fatigue are thought to set the limit and the majority of …

Fashions in ideas, like clothes, come and go. From approximately 1950–1980, physiological
research was seen as the key discipline in understanding lung disease and was at the …

Key points The oxygen cost of breathing represents a significant fraction of total oxygen
uptake during intense exercise. At a given ventilation, women have a greater work of …

Background: Dynamic hyperinflation of the lungs impairs exercise performance in chronic
obstructive pulmonary disease (COPD). However, it is unclear which patients are affected by …

Background Pursed-lip breathing (PLB) is a strategy often spontaneously employed by
patients with COPD during distress situations. Whether and to what extent PLB affects …

No doubt dynamic hyperinflation and lack of oxidative capacity of skeletal muscles are
important causes of exercise limitation in COPD. O'Donnell and Webb and Debigaré and …

Non‐technical summary Cough is the commonest symptom for which people seek medical
advice and has significant impact upon quality of life. Moreover ineffective coughing is …

Although the measurement of pulmonary ventilation by a spirometer or a
pneumotachograph may appear to be a simple procedure, it is much more complicated than …

This review examines 18 studies published≥ 30 yrs ago. They show that the earliest
manifestation of chronic obstructive pulmonary disease (COPD) is an increase in residual …

Background: Not all patients with severe chronic obstructive pulmonary disease (COPD)
progressively hyperinflate during symptom limited exercise. The pattern of change in chest …