Fungi are often inconspicuous in nature and this means it is all too easy to overlook their
importance. Often referred to as the “Forgotten Kingdom”, fungi are key components of life …

Secondary metabolites of higher fungi (mushrooms) are an underexplored resource
compared to plant-derived secondary metabolites. An increasing interest in mushroom …

The quaternization of compounds has emerged as a promising molecular design strategy for
the development of antibiotics. Herein, we report the design, synthesis, antibacterial …

Sulfur-containing compounds are commonly present in both natural and synthetic bioactive
molecules. The ability to construct C–S bonds using inexpensive and easily accessible raw …

BACKGROUND The literature shows that bisthioether and 1, 3, 4‐oxadiazole derivatives
exhibit a wide variety of biological activities. In this study, a series of novel bisthioether …

Covering: up to 2018 Pleuromutilins are a clinically validated class of antibiotics derived
from the fungal diterpene (+)-pleuromutilin (1). Pleuromutilins inhibit bacterial protein …

The rise in antibiotic resistance is a major threat for human health. Basidiomycete fungi
represent an untapped source of underexploited antimicrobials, with pleuromutilin—a …

Semi-synthetic derivatives of the tricyclic diterpene antibiotic pleuromutilin from the
basidiomycete Clitopilus passeckerianus are important in combatting bacterial infections in …

Metal catalysis, a common approach in conventional organic synthesis, poses a challenge
in DEL chemistry due to the vulnerability of DNA fragments and the requirement of aqueous …

Rapid emergence of multidrug resistant Staphylococcus aureus infections has created a
critical health menace universally. Resistance to all the available chemotherapeutics has …