Lyme disease (Lyme borreliosis) is a tick-borne, zoonosis of adults and children caused by
genospecies of the Borrelia burgdorferi sensu lato complex. The ailment, widespread …

CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an
important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells …

CXCR3 is a chemokine receptor that is rapidly induced on naïve T cells following activation,
and preferentially remains highly expressed on type‐1 helper (Th1)‐type CD4+ T cells …

Infectious agents can trigger autoimmune responses in a number of chronic inflammatory
diseases. Lyme arthritis, which is caused by the tick-transmitted spirochaete Borrelia …

BACKGROUND Autoimmune diseases often have strong genetic associations with specific
HLA-DR alleles. The synovial lesion in chronic inflammatory forms of arthritis shows marked …

Lyme disease is a multisystem disorder caused by the spirochete Borrelia burgdorferi. A
common late-stage complication of this disease is oligoarticular arthritis, often involving the …

Lyme disease was originally identified in Lyme, Connecticut, based upon an unusual cluster
of what appeared to be patients with juvenile rheumatoid arthritis. It was subsequently …

Lyme disease is an infection caused by Borrelia burgdorferi sensu lato, which is transmitted
to humans through the bite of an infected Ixodes tick. The majority of patients recover without …

Abstract Objective Single‐nucleotide polymorphisms (SNPs) that alter immune function,
inflammatory responses, and disease susceptibility have been identified in several genes …

It is widely believed that innate immune responses to Borrelia burgdorferi (Bb) are primarily
triggered by the spirochete's outer membrane lipoproteins signaling through cell surface …